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Climara

What are Climara patches

Estradiol (a form of estrogen) is a female sex hormone necessary for many processes in the body.

Climara is prescribed to treat the symptoms of menopause; deficiencies in ovary function, including some types of infertility and abnormal vaginal bleeding disorders; and vaginal or urethral dryness, itchiness, and burning caused by hormonal deficiencies. Some estradiol topical patches are also used to prevent postmenopausal osteoporosis. Transdermal patches release the drug slowly, and estrogen is absorbed through your skin.

Estradiol topical patches may also be used for purposes other than those listed in this medication guide.

General medical information about Climara patches

Climara increases the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, while using Climara lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together while using Climara. Visit your doctor regularly and report any unusual vaginal bleeding right away.

Have yearly physical exams and examine your breasts for lumps on a monthly basis while using Climara patches.

Do not use this medication if you are pregnant.

Do not place the transdermal patch on your breasts or at your waistline where tight-fitting clothing may interfere with its functioning.

Who should not use Climara patches

Do not use Climara patches without first talking to your doctor if you have
- a circulation, bleeding, or blood-clotting disorder;
- undiagnosed, abnormal vaginal bleeding; or
- any type of breast, uterine, or hormone-dependent cancer.

Using Climara patches may be dangerous in some cases if you have any of the conditions listed above.

Before using an estradiol topical patch, tell your doctor if you have:
- high blood pressure, angina, or heart disease;
- high levels of cholesterol or triglycerides in your blood;
- liver disease;
- kidney disease;
- asthma;
- epilepsy;
- migraines;
- depression;
- diabetes;
- gallbladder disease;
- uterine fibroids; or
- had a hysterectomy (uterus removed).

You may not be able to use Climara patches, or you may need a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Estradiol is in the FDA pregnancy category X. This means that estradiol will cause birth defects in an unborn baby. Do not use Climara patches if you are pregnant or are planning a pregnancy.

Estradiol may decrease milk flow and have other effects on milk composition. Do not use Climara patches without first talking to your doctor if you are breast-feeding a baby.

How should you use Climara patches

Use Climara patches exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Remove the protective backing from the patch as directed. Avoid handing the sticky side of the patch. Apply the patch immediately after removing it from the pouch.

Apply each patch to a clean, dry area on your abdomen, buttocks, inner thigh, upper arm, or hips as directed for the particular product you are using. Do not use the patch on your breasts or at your waistline,

Where clothing may interfere with its use. Follow the specific directions for application included with your patch.

Press the patch firmly into place with the palm of your hand for about 10 seconds, making sure there is good contact, especially around the edges.

You will either use one patch for 7 days or one patch for half of the week and another patch for the other half of the week, depending on which brand of patch you are using. Follow your doctor's instructions or ask your pharmacist for help if you do not remember. If you are using two patches per week, remember always to change the patches on the same days of the week. Allow at least 1 week to pass between applications of the patch to a given area.

Do not cut the patches.

When removing the patch, peel off the used patch slowly. Fold the used patch in half (sticky sides together) and throw it away out of the reach of children and pets.

Bathing, showering, or swimming should not affect the patch, although a long, hot bath may cause it to fall off. If a patch falls off for any reason, reapply it to the same site. If it will not stick, apply a new patch to a new site. Continue changing the patch on your regular schedule.

Have yearly physical exams and examine your breasts for lumps on a monthly basis while using Climara patches.

Store the Climara patches in their pouches at room temperature away from moisture and heat.

If you miss a dose:

Apply the next patch soon as you remember. Continue to follow your regular schedule for changing the patch. Do not use two patches simultaneously unless your doctor directs otherwise.

If a patch falls off for any reason, reapply it to the same site. If it will not stick, apply a new patch to a new site. Continue changing the patch on your regular schedule.

What happens if you overdose:

An overdose of estradiol is unlikely to occur and is not likely to threaten life. If you do suspect an overdose, or if the patch has been ingested, call an emergency room or poison control center for advice.

What should you avoid while using Climara patches

There are no restrictions on food, beverages, or activity while using Climara patches unless your doctor directs otherwise.

Possible side effects of Climara patches

If you experience any of the following serious side effects, stop using Climara patches and seek emergency medical attention:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
- shortness or breath or pain in your chest;
- a painful, red, swollen leg;
- abnormal vaginal bleeding;
- pain, swelling, or tenderness in the abdomen;
- severe headache or vomiting, dizziness, faintness or changes in vision or speech;
- yellowing of the skin or eyes; or
- a lump in a breast.

Other, less serious side effects may be more likely to occur. Continue to use Climara patches and talk to your doctor if you experience
- decreased appetite, nausea, or vomiting;
- swollen breasts;
- acne or skin color changes;
- decreased sex drive;
- migraine headaches or dizziness;
- vaginal pain, dryness, or discomfort;
- water retention (swollen hands, feet, or ankles);
- irritation at the application site;
- depression; or
- changes in your menstrual cycle or break-through bleeding.

Estradiol increases the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, while using estradiol lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take while using Climara patches. Visit your doctor regularly and report any unusual vaginal bleeding right away.

It is unclear to

What extent estrogen treatments may affect the risk of breast cancer.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Climara patches

Before using Climara patches, tell your doctor if you are taking any of the following medicines:
- an anticoagulant (blood thinner) such as warfarin (Coumadin);
- a thyroid medication such as Synthroid, Levoxyl, Levothroid, and others;
- insulin or an oral diabetes medicine such as glipizide (Glucotrol) and glyburide (Diabeta, Micronase);
- tamoxifen (Nolvadex);
- a tricyclic antidepressant such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), imipramine (Tofranil), and others;
- didanosine (Videx);
- phenytoin (Dilantin) or ethotoin (Peganone);
- carbamazepine (Tegretol);
- phenobarbital (Solfoton, Luminal);
- primidone (Mysoline); or
- rifampin (Rifadin).

A dosage adjustment or special monitoring may be required during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with Climara patches. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

All prescription drugs:

A
abilify accupril accutane acetaminophen aciphex actifed actonel actos acyclovir adalat adderall adipex advair advil albuterol alesse aleve allegra allopurinol amaryl ambien amiodarone amitriptyline amoxicillin amoxil amphetamine anacin aprazolam aricept asacol aspirin atenolol ativan atorvastatin atrovent augmentin avandia avapro avastin avelox azmacort
B
baclofen
bactrim bactroban baycol benadryl bextra biaxin boniva bontril buspar buspirone
C
caduet campral camptosar capoten captopril cardizem cardura carisoprodol casodex catapress cefzil celebrex celexa cellcept cephalexin cialis cipro ciprodex clarinex claritin climara clindamycin clonazepam clonidine codeine codeprex combivent combivir concerta copaxone coreg coricidin cotrim coumadin cozaar crestor cubicin cyclobenzaprine cymbalta
D
darvocet demerol depakote desogen detrol dextromethorphan diazepam diclofenac didrex diflucan digoxin dilantin diltiazem dimetapp diovan diprivan ditropan doxazosin doxycycline drixoral duragesic dyazide
E
effexor elavil elocon eloxatin emend enalapril enbrel endocet engerix-b entex epogen epzicom erbitux ertaczo ery-tab erythromycin estradiol evista 
F
fabrazyme famotidine fazaclo fenofibrate fioricet fiorinal flexeril flomax flonase flovent fluoxetine fosamax fosrenol furosemide  
G
gabapentin gamimune gemfibrozil gemzar glipizide glucophage glucotrol glucovance glyburide glyburide guaifenesin guaifenex 
H
herceptin humalog humira hydroxyzine hyzaar  
I
ibuprofen imdur imitrex imodium inderal insulin integrilin iressa 
K
kaletra keflex kenalog keppra ketek klonopin kytril  
L
lamictal lamisil lanoxin lantus lasix lescol levaquin levitra levothyroxine levoxyl lexapro lidoderm lipitor lisinopril lithium lorazepam lortab lotensin lotrel lotrisone lovenox lupron luveris  
M
macrobid magnevist meclizine medroxyprogesterone meridia metformin methadone methamphetamine methotrexate methylphenidate methylprednisolone metoclopramide metoprolol metronidazole miacalcin minocycline mobic monopril morphine motrin myfortic  
N
naproxen nasacort nasonex natrecor neulasta neupogen neurontin nexium nifedipine nitrofurantoin norco nortriptyline norvasc  
O
omeprazole omnicef orthovisc oxybutynin oxycodone oxycontin oxytrol  
P
paraplatin patanol paxil pegasys penicillin pepcid percocet percodan percogesic phendimetrazine phenergan phentermine phenytoin plavix plendil potassium pravachol prednisone premarin prempro prevacid prilosec prinivil procrit promethazine propecia propofol propoxyphene propranolol protonix proventil provigil prozac pseudoephedrine pulmicort  
R
ranitidine rebetol reglan relafen relpax remeron remicade renagel renova rhinocort riomet risperdal risperidone ritalin rituxan rocephin rogaine roxicet  
S
sanctura seasonale sensipar serevent seroquel serzone singulair skelaxin soma somavert sonata spiriva spironolactone strattera striant sustiva synagis synthroid 
T
tamoxifen tavist taxol taxotere tegretol temazepam tenormin tenuate tequin terazosin tetracycline tiazac tindamax titralac tobradex topamax toprol tramadol trazodone triamcinolone triaminic triamterene tricor trileptal trimox triphasil trizivir truvada tylenol 
U
ultane ultracet ultram uroxatral
V
valium valtrex vaniqa vasotec velcade verapamil viagra vicodin vicoprofen vidaza viracept viread vytorin  
W
warfarin wellbutrin  
X
xalatan xanax xenical xifaxan xolair xopenex xyrem  
Y
yasmin 
Z
zanaflex zantac zavesca zelnorm zemplar zerit zestoretic zestril zetia ziac zithromax zocor zofran zoladex zoloft zometa zorbtive zosyn zovirax zyrtec zyvox