What is Combivent
is a bronchodilator. It relaxes muscles in the airways, which
improves breathing. Ipratropium is used to prevent bronchospasm,
which narrows airways. By preventing narrowing of the airways,
ipratropium increases air flow to the lungs.
is used to treat chronic obstructive pulmonary disease (COPD).
may also be used for conditions other than those listed in
this medication guide.
General medical information about Combivent
It is very important that the Combivent inhaler or
nebulized solution is used properly, so that the medicine
gets into the lungs. Your doctor may want you to use a spacer
with the inhaler. Talk to your doctor about proper inhaler
or nebulizer use.
Seek medical attention if you notice
that you require more than your usual or more than the maximum
amount of any chronic obstructive pulmonary disease (COPD)
medication in a 24-hour period. An increased need for medication
could be an early sign of worsening lung function.
Do not use the Combivent inhaler if you have a soya lecithin
allergy (e.g., an allergy to soybeans or peanuts).
What you should discuss with your doctor before
using Combivent Do not use the Combivent Inhaler if you have a soya
lecithin allergy (e.g., an allergy to soybeans or peanuts).
Before using this medication, tell your doctor if you have:
- heart disease or high blood pressure,
- epilepsy or another seizure disorder,
- an overactive thyroid (hyperthyroidism),
- glaucoma (the narrow-angle form),
- an enlarged
prostate or a bladder obstruction, or
- liver or
You may require a dosage adjustment
or special monitoring during treatment if you have any of
the conditions listed above.
Combivent is in the
FDA pregnancy category C. This means that it is not known
whether it will be harmful to an unborn baby. Do not use
this medication without first talking to your doctor if
you are pregnant or could become pregnant during treatment.
It is not known whether Combivent passes into breast
milk. Do not use Combivent without first talking to your
doctor if you are breast-feeding a baby.
How should you use Combivent Use Combivent exactly as directed by your doctor.
If you do not understand these directions, ask your pharmacist,
nurse, or doctor to explain them to you.
To use the
- You may want to "test-spray"
the inhalation unit three times before using it for the
first time and if it has not been used for 24 hours or more.
Doing so will ensure that your first dose will deliver the
proper amount of medication.
- Shake the inhaler
several times and uncap the mouthpiece. Breathe out fully.
Put the mouthpiece of the inhaler or spacer into your mouth.
Be sure the mouthpiece is above the tongue and past the
teeth. Alternatively, place the inhaler (not spacer) several
inches in front of your open mouth, if directed to do so
by your doctor. Take a deep, slow breath as you push down
on the canister. Hold your breath for 10 seconds, then exhale
- If your doses consist of more than one
puff each, wait approximately 2 minutes, shake the inhaler
again, then repeat the inhalation procedure.
the inhaler away after 200 inhalations. The amount of medication
in each inhalation cannot be assured after 200 sprays.
To use the solution for nebulization:
- Open one
ampule (or the prescribed amount of medication) and empty
it into the medication chamber of the nebulizer.
Attach the mouthpiece or face mask to the drug chamber.
Then, attach the drug chamber to the compressor. Sit upright,
in a comfortable position, and put the mouthpiece into your
mouth or put the face mask on, covering the nose and mouth.
Breathe slowly and evenly until all of the medicine has
been inhaled (usually 5 to 15 minutes). The treatment is
complete when no more mist is formed by the nebulizer and
the drug chamber is empty.
- Clean the nebulizer
after each treatment as directed by the manufacturer.
If you also use a steroid inhaler, use the Combivent inhaler
first to open up the airways, then use the steroid inhaler
as directed unless otherwise directed by your doctor.
It is important to use Combivent regularly to get the most
It is very important that the Combivent
inhaler or nebulized solution is used properly, so that
the medicine gets into the lungs. Your doctor may want you
to use a spacer with the inhaler. Talk to your doctor about
proper inhaler or nebulizer use.
Do not use more
of this medication than is prescribed.
attention if you notice that you require more than your
usual or more than the maximum amount of any medication
for chronic obstructive pulmonary disease (COPD) in a 24-hour
period. An increased need for medication could be an early
sign of worsening lung function.
Your doctor may
want you to have lung function tests or other medical evaluations
during treatment with Combivent to monitor progress and
Keep the inhaler clean and dry. Keep
the mouthpiece capped to avoid getting dirt inside it. Clean
the inhaler when necessary by removing the canister and
immersing the mouthpiece in warm water. Allow the parts
to dry, then reassemble the inhaler.
Carry the inhaler
with you at all times in case of emergencies. Get a refill
before you run out of medicine and before going on vacation.
Store the inhaler or solution for nebulization at
room temperature protected from light, moisture, and heat.
If you miss a dose: Use the missed dose as soon as you remember. However,
if it is almost time for the next regularly scheduled dose,
skip the missed dose and use the next one as directed. Do
not use a double dose of this medication.
are using Combivent on an as needed basis, use the missed
dose when it is needed, then wait the prescribed amount
of time before using another dose.
What happens if you overdose: Seek emergency medical attention if an overdose is
Symptoms of an overdose of Combivent include
angina or chest pain, irregular heartbeats or a fluttering
heart, seizures, tremor, weakness, headache, nausea, and
What should you avoid while using Combivent Avoid situations that may trigger an asthma attack,
such as exercising in cold, dry air; smoking; breathing
in dust; and exposure to allergens such as pet hair.
Avoid getting this medication in your eyes. Albuterol and
ipratropium in the eyes may cause eye pain, blurred vision,
dilated pupils, and unusual color perception. If medication
gets into the eyes, rinse the eyes with water and seek medical
Possible side effects of Combivent Stop using Combivent and seek emergency medical attention
or contact your doctor immediately if you experience any
of the following serious side effects:
- an allergic
reaction (difficulty breathing; closing of the throat; swelling
of the lips, tongue, or face; or hives); or
pain or irregular heartbeats.
Other, less serious
side effects may be more likely to occur. Continue to use
Combivent and talk to your doctor if you experience
headache or dizziness;
- blurred vision;
vomiting, diarrhea, or constipation; or
- dry mouth
Side effects other than those listed here
may also occur. Talk to your doctor about any side effect
that seems unusual or that is especially bothersome.
What other drugs will affect Combivent Before using this medication, tell your doctor if
you are taking any of the following medicines:
a beta-blocker such as acebutolol (Sectral), atenolol (Tenormin),
carvedilol (Coreg), metoprolol (Lopressor), propranolol
(Inderal), and others;
- a diuretic (water pill)
such as furosemide (Lasix), bumetanide (Bumex), ethacrynic
acid (Edecrin), torsemide (Demadex), hydrochlorothiazide
(Hydrodiuril), chlorthalidone (Hygroton, Thalitone), chlorothiazide
(Diuril), and others;
- a tricyclic antidepressant
such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline
(Pamelor), and others;
- a monoamine oxidase inhibitor
(MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil),
or tranylcypromine (Parnate);
- a medicine such as
atropine, belladonna, clidinium (Quarzan), dicyclomine (Bentyl),
scopolamine (Transderm-Scop), propantheline (Pro-Banthine),
mepenzolate (Cantil), methantheline (Banthine), methscopolamine
(Pamine), and others; or
- caffeine, diet pills,
You may not be able to use Combivent,
or you may require a dosage adjustment or special monitoring
other than those listed here may also interact with Combivent,
or affect your condition. Talk to your doctor and pharmacist
before taking any prescription or over-the-counter medicines,
including vitamins, minerals and herbal products.