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Combivir

What is Combivir

Lamivudine and zidovudine are antiviral medications. They are in a category of HIV medicines called reverse transcriptase inhibitors. Lamivudine and zidovudine inhibit the reproduction of HIV in the body.

Lamivudine and zidovudine are used together to treat the human immunodeficiency virus (HIV), which causes the acquired immunodeficiency syndrome (AIDS). Combivir is not a cure for HIV or AIDS.

Combivir may also be used for purposes other than those listed in this medication guide.

General medical information about Combivir

Serious blood problems including low levels of red and/or white blood cells have occurred with the use of zidovudine. Contact your doctor immediately if you develop unusual fatigue, pale skin, sore throat, fever, or chills which may be signs of blood problems.

Lactic acidosis and severe liver problems, including fatal cases, have been reported with the use of Combivir, alone or in combination. Contact your doctor immediately if you experience nausea, vomiting, or unusual or unexpected stomach discomfort; weakness and tiredness; shortness of breath; weakness in the arms and legs; yellowing of the skin or eyes; or pain in the upper stomach area. These may be early symptoms of lactic acidosis or liver problems.

Serious, even fatal, cases of pancreatitis (inflammation of the pancreas) have been reported with the use of some reverse transcriptase inhibitors. Notify your doctor immediately if you develop symptoms of pancreatitis including nausea, vomiting, diarrhea, abdominal pain, and/or fever.

Avoid alcohol while taking Combivir. Alcohol may increase the risk of damage to the pancreas and/or liver.

Follow your doctor's instructions with respect to high-risk activities such as unprotected sex and the sharing of needles. Combivir is not a cure for HIV or AIDS, and you can still transmit the virus to others during therapy with this medication.

What you should find out before taking Combivir

Before taking Combivir, tell your doctor if you
- have kidney disease;
- have liver disease;
- have hepatitis;
- have bone marrow suppression; or
- weigh less than 110 pounds (50 kg).

You may not be able to take Combivir, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Combivir is in the FDA pregnancy category C. This means that it is not known whether Combivir will be harmful to an unborn baby. It is very important to treat HIV/AIDS during pregnancy to reduce the risk of infecting the baby. Talk to your doctor about your treatment options.

It is not known whether Combivir passes into breast milk and

What effect it may have on a nursing baby. To prevent transmission of the virus to uninfected babies, it is recommended that HIV-positive mothers not breast-feed.

How should take Combivir

Take Combivir exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Combivir can be taken with or without food.

Combivir is usually taken twice a day. Follow your doctor's instructions.

It is important to take Combivir regularly to get the most benefit.

Treatment of HIV/AIDS almost always requires the use of two or more drugs. If you need to stop taking one of the medicines you are taking for HIV, you should stop all of them until you can talk to your doctor.

Your doctor may want you to have blood tests or other medical evaluations during treatment with Combivir to monitor progress and side effects.

Store Combivir at room temperature away from moisture and heat.

If you miss a dose:

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication unless your doctor directs otherwise.

What happens if you overdose:

Seek emergency medical attention if an overdose is suspected.

Symptoms of a Combivir overdose may include nausea, vomiting, headache, dizziness, drowsiness, lethargy, confusion, and seizures.

Avoid while taking Combivir

Follow your doctor's instructions with respect to high-risk activities such as unprotected sex and the sharing of needles. Combivir does not cure HIV or AIDS and you can still transmit the virus to others during therapy with this medication.

Avoid alcohol while taking Combivir. Alcohol may increase the risk of damage to the pancreas and/or liver.

Possible side effects of Combivir

Serious blood problems including low levels of red and/or white blood cells have occurred with the use of zidovudine. Contact your doctor immediately if you develop unusual fatigue, pale skin, sore throat, fever, or chills which may be signs of blood problems.

Lactic acidosis and severe liver problems, including fatal cases, have been reported with the use of reverse transcriptase inhibitors, alone or in combination. Contact your doctor immediately if you experience nausea, vomiting, or unusual or unexpected stomach discomfort; weakness and tiredness; shortness of breath; weakness in the arms and legs; yellowing of the skin or eyes; or pain in the upper stomach area. These may be early symptoms of lactic acidosis or liver problems.

Serious, even fatal, cases of pancreatitis (inflammation of the pancreas) have been reported with the use of some reverse transcriptase inhibitors. Notify your doctor immediately if you develop symptoms of pancreatitis including nausea, vomiting, diarrhea, abdominal pain, and/or fever.

If you experience any of the following serious side effects, stop taking Combivir and seek emergency medical attention or notify your doctor immediately:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- muscle pain or weakness; or
- peripheral neuropathy (nerve damage), which may cause numbness, tingling, or pain.

Other, less serious side effects may be more likely to occur. Continue taking Combivir and talk to your doctor if you experience
- mild nausea, vomiting, diarrhea, or decreased appetite;
- a headache;
- dizziness;
- insomnia; or
- redistribution of body fat (loss of fat from the arms, legs, and face and increased fat around the neck, breast, and trunk).

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Combivir

Other medications may interact with Combivir resulting in decreased effectiveness and/or side effects. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, during treatment with Combivir.

All prescription drugs:

A
abilify accupril accutane acetaminophen aciphex actifed actonel actos acyclovir adalat adderall adipex advair advil albuterol alesse aleve allegra allopurinol amaryl ambien amiodarone amitriptyline amoxicillin amoxil amphetamine anacin aprazolam aricept asacol aspirin atenolol ativan atorvastatin atrovent augmentin avandia avapro avastin avelox azmacort
B
baclofen
bactrim bactroban baycol benadryl bextra biaxin boniva bontril buspar buspirone
C
caduet campral camptosar capoten captopril cardizem cardura carisoprodol casodex catapress cefzil celebrex celexa cellcept cephalexin cialis cipro ciprodex clarinex claritin climara clindamycin clonazepam clonidine codeine codeprex combivent combivir concerta copaxone coreg coricidin cotrim coumadin cozaar crestor cubicin cyclobenzaprine cymbalta
D
darvocet demerol depakote desogen detrol dextromethorphan diazepam diclofenac didrex diflucan digoxin dilantin diltiazem dimetapp diovan diprivan ditropan doxazosin doxycycline drixoral duragesic dyazide
E
effexor elavil elocon eloxatin emend enalapril enbrel endocet engerix-b entex epogen epzicom erbitux ertaczo ery-tab erythromycin estradiol evista 
F
fabrazyme famotidine fazaclo fenofibrate fioricet fiorinal flexeril flomax flonase flovent fluoxetine fosamax fosrenol furosemide  
G
gabapentin gamimune gemfibrozil gemzar glipizide glucophage glucotrol glucovance glyburide glyburide guaifenesin guaifenex 
H
herceptin humalog humira hydroxyzine hyzaar  
I
ibuprofen imdur imitrex imodium inderal insulin integrilin iressa 
K
kaletra keflex kenalog keppra ketek klonopin kytril  
L
lamictal lamisil lanoxin lantus lasix lescol levaquin levitra levothyroxine levoxyl lexapro lidoderm lipitor lisinopril lithium lorazepam lortab lotensin lotrel lotrisone lovenox lupron luveris  
M
macrobid magnevist meclizine medroxyprogesterone meridia metformin methadone methamphetamine methotrexate methylphenidate methylprednisolone metoclopramide metoprolol metronidazole miacalcin minocycline mobic monopril morphine motrin myfortic  
N
naproxen nasacort nasonex natrecor neulasta neupogen neurontin nexium nifedipine nitrofurantoin norco nortriptyline norvasc  
O
omeprazole omnicef orthovisc oxybutynin oxycodone oxycontin oxytrol  
P
paraplatin patanol paxil pegasys penicillin pepcid percocet percodan percogesic phendimetrazine phenergan phentermine phenytoin plavix plendil potassium pravachol prednisone premarin prempro prevacid prilosec prinivil procrit promethazine propecia propofol propoxyphene propranolol protonix proventil provigil prozac pseudoephedrine pulmicort  
R
ranitidine rebetol reglan relafen relpax remeron remicade renagel renova rhinocort riomet risperdal risperidone ritalin rituxan rocephin rogaine roxicet  
S
sanctura seasonale sensipar serevent seroquel serzone singulair skelaxin soma somavert sonata spiriva spironolactone strattera striant sustiva synagis synthroid 
T
tamoxifen tavist taxol taxotere tegretol temazepam tenormin tenuate tequin terazosin tetracycline tiazac tindamax titralac tobradex topamax toprol tramadol trazodone triamcinolone triaminic triamterene tricor trileptal trimox triphasil trizivir truvada tylenol 
U
ultane ultracet ultram uroxatral
V
valium valtrex vaniqa vasotec velcade verapamil viagra vicodin vicoprofen vidaza viracept viread vytorin  
W
warfarin wellbutrin  
X
xalatan xanax xenical xifaxan xolair xopenex xyrem  
Y
yasmin 
Z
zanaflex zantac zavesca zelnorm zemplar zerit zestoretic zestril zetia ziac zithromax zocor zofran zoladex zoloft zometa zorbtive zosyn zovirax zyrtec zyvox