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Diclofenac

What is diclofenac

Diclofenac is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac works by reducing hormones that cause inflammation and pain in the body.

Diclofenac is used to reduce pain, inflammation and stiffness caused by many conditions, such as osteoarthritis, rheumatoid arthritis, abdominal cramps associated with menstruation, and ankylosing spondylitis.

Diclofenac may also be used for purposes other than those listed in this medication guide.

General medical information about diclofenac

Take diclofenac with food, milk, or an antacid to lessen stomach upset.

Do not crush, chew, or break diclofenac tablets. Swallow them whole.

Remain upright (sitting or standing) for 15 to 30 minutes after each dose to prevent irritation of your esophagus (throat).

Watch for bloody, black, or tarry stools or blood in your vomit. These symptoms could indicate damage to your stomach.

If you drink more than three alcoholic beverages a day, diclofenac may increase the risk of stomach bleeding.

Who should not take diclofenac

Before taking this medication, tell your doctor if you
- have an allergy to aspirin or any other NSAIDs,
- have an ulcer or bleeding in your stomach,
- drink more than three alcoholic beverages a day,
- have liver or kidney disease,
- have a coagulation (bleeding) disorder,
- have congestive heart failure,
- have fluid retention,
- have heart disease, or
- have high blood pressure.

You may not be able to take diclofenac, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Diclofenac is in the FDA pregnancy category B. This means that it is not expected to cause harm to an unborn baby. Diclofenac must not be taken late in pregnancy (the third trimester) because a similar drug is known to affect the baby's heart. Do not take diclofenac without first talking to your doctor if you are pregnant.

Diclofenac passes into breast milk. Do not take diclofenac without first talking to your doctor if you are breast-feeding a baby.

How should take diclofenac

Take diclofenac exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Take diclofenac with food, milk, or an antacid to lessen stomach upset.

Do not crush, break, or chew diclofenac tablets. Swallow them whole.

To prevent irritation of your esophagus (throat), do not lie down for 15 to 30 minutes after taking diclofenac.

Store diclofenac at room temperature away from moisture and heat.

If you miss a dose:

Take the missed dose as soon as you remember up to 2 hours late. If more than 2 hours have passed since the missed dose, skip it and take only your next regularly scheduled dose. Do not take a double dose.

What happens if you overdose:

Seek emergency medical attention.

Symptoms of a diclofenac overdose include nausea, vomiting, stomach pain, dizziness, drowsiness, headache, ringing in the ears, blurred vision, seizures, sweating, numbness or tingling, little or no urine production, and slow breathing.

Avoid while taking diclofenac

Avoid prolonged exposure to sunlight. Diclofenac may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

If you drink more than three alcoholic beverages a day, diclofenac may increase the risk of stomach bleeding.

Possible side effects of diclofenac

If you experience any of the following serious side effects, stop taking diclofenac and seek medical treatment or call your doctor immediately:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
- muscle cramps, numbness, or tingling;
- ulcers (open sores) in the mouth;
- rapid weight gain (fluid retention);
- seizures;
- black, bloody, or tarry stools;
- blood in your urine or vomit;
- decreased hearing or ringing in the ears;
- yellowing of the skin and eyes (jaundice); or
- abdominal cramping, indigestion, or heartburn.

Other, less serious side effects may be more likely to occur. Continue to take diclofenac and talk to your doctor if you experience
- dizziness or headache;
- nausea, gaseousness, diarrhea, or constipation;
- depression;
- fatigue or weakness;
- dry mouth; or
- irregular menstrual periods.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect diclofenac

Other prescription and over-the-counter drugs may increase the effects of diclofenac and cause dangerous side effects. Tell your doctor if you are taking any of the following drugs:
- other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Rufen, others), ketoprofen (Orudis, Orudis KT, Oruvail), or naproxen (Naprosyn, Aleve, Anaprox);
- other commonly used NSAIDs, including etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin);
- aspirin and other salicylates (forms of aspirin) such as salsalate (Disalcid), choline salicylate, and magnesium salicylate (watch the aspirin content of other over-the-counter products such as cough, cold, and allergy medicines);
- diuretics (water pills) such as hydrochlorothiazide (HCTZ, Hydrodiuril, others), chlorothiazide (Diuril, others), chlorthalidone (Thalitone), bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix), spironolactone (Aldactone), and amiloride (Midamor);
- anticoagulants such as warfarin (Coumadin);
- steroids such as prednisone (Deltasone);
- alcohol;
- oral antidiabetic drugs such as glipizide (Glucotrol) and glyburide (Micronase, Diabeta);
- lithium (Eskalith, Lithobid, others);
- cyclosporine (Sandimmune, Neoral); or
- bismuth subsalicylate in drugs such as Pepto-Bismol.

Diclofenac can also decrease the effects of other drugs, such as
- angiotensin-converting-enzyme (ACE) inhibitors, used to treat high blood pressure and other conditions, such as benazepril (Lotensin) and captopril (Capoten);
- other commonly used ACE inhibitors, including enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), quinapril (Accupril), and ramipril (Altace); and
- beta-blockers, used to treat high blood pressure and other conditions, such as acebutolol (Sectral), metoprolol (Lopressor), propranolol (Inderal), atenolol (Tenormin), and carteolol (Cartrol).

Drugs other than those listed here may also interact with diclofenac. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

All prescription drugs:

A
abilify accupril accutane acetaminophen aciphex actifed actonel actos acyclovir adalat adderall adipex advair advil albuterol alesse aleve allegra allopurinol amaryl ambien amiodarone amitriptyline amoxicillin amoxil amphetamine anacin aprazolam aricept asacol aspirin atenolol ativan atorvastatin atrovent augmentin avandia avapro avastin avelox azmacort
B
baclofen
bactrim bactroban baycol benadryl bextra biaxin boniva bontril buspar buspirone
C
caduet campral camptosar capoten captopril cardizem cardura carisoprodol casodex catapress cefzil celebrex celexa cellcept cephalexin cialis cipro ciprodex clarinex claritin climara clindamycin clonazepam clonidine codeine codeprex combivent combivir concerta copaxone coreg coricidin cotrim coumadin cozaar crestor cubicin cyclobenzaprine cymbalta
D
darvocet demerol depakote desogen detrol dextromethorphan diazepam diclofenac didrex diflucan digoxin dilantin diltiazem dimetapp diovan diprivan ditropan doxazosin doxycycline drixoral duragesic dyazide
E
effexor elavil elocon eloxatin emend enalapril enbrel endocet engerix-b entex epogen epzicom erbitux ertaczo ery-tab erythromycin estradiol evista 
F
fabrazyme famotidine fazaclo fenofibrate fioricet fiorinal flexeril flomax flonase flovent fluoxetine fosamax fosrenol furosemide  
G
gabapentin gamimune gemfibrozil gemzar glipizide glucophage glucotrol glucovance glyburide glyburide guaifenesin guaifenex 
H
herceptin humalog humira hydroxyzine hyzaar  
I
ibuprofen imdur imitrex imodium inderal insulin integrilin iressa 
K
kaletra keflex kenalog keppra ketek klonopin kytril  
L
lamictal lamisil lanoxin lantus lasix lescol levaquin levitra levothyroxine levoxyl lexapro lidoderm lipitor lisinopril lithium lorazepam lortab lotensin lotrel lotrisone lovenox lupron luveris  
M
macrobid magnevist meclizine medroxyprogesterone meridia metformin methadone methamphetamine methotrexate methylphenidate methylprednisolone metoclopramide metoprolol metronidazole miacalcin minocycline mobic monopril morphine motrin myfortic  
N
naproxen nasacort nasonex natrecor neulasta neupogen neurontin nexium nifedipine nitrofurantoin norco nortriptyline norvasc  
O
omeprazole omnicef orthovisc oxybutynin oxycodone oxycontin oxytrol  
P
paraplatin patanol paxil pegasys penicillin pepcid percocet percodan percogesic phendimetrazine phenergan phentermine phenytoin plavix plendil potassium pravachol prednisone premarin prempro prevacid prilosec prinivil procrit promethazine propecia propofol propoxyphene propranolol protonix proventil provigil prozac pseudoephedrine pulmicort  
R
ranitidine rebetol reglan relafen relpax remeron remicade renagel renova rhinocort riomet risperdal risperidone ritalin rituxan rocephin rogaine roxicet  
S
sanctura seasonale sensipar serevent seroquel serzone singulair skelaxin soma somavert sonata spiriva spironolactone strattera striant sustiva synagis synthroid 
T
tamoxifen tavist taxol taxotere tegretol temazepam tenormin tenuate tequin terazosin tetracycline tiazac tindamax titralac tobradex topamax toprol tramadol trazodone triamcinolone triaminic triamterene tricor trileptal trimox triphasil trizivir truvada tylenol 
U
ultane ultracet ultram uroxatral
V
valium valtrex vaniqa vasotec velcade verapamil viagra vicodin vicoprofen vidaza viracept viread vytorin  
W
warfarin wellbutrin  
X
xalatan xanax xenical xifaxan xolair xopenex xyrem  
Y
yasmin 
Z
zanaflex zantac zavesca zelnorm zemplar zerit zestoretic zestril zetia ziac zithromax zocor zofran zoladex zoloft zometa zorbtive zosyn zovirax zyrtec zyvox