What is Dyazide
is a thiazide diuretic (water pill). It decreases the amount
of fluid in your body by increasing the amount of salt and
water you lose in your urine.
is a potassium-sparing diuretic (also water pill). It is used
to reduce the amount of fluid in the body without causing
the loss of potassium.
is used to treat edema (swelling) and hypertension (high blood
may also be used for purposes other than those listed in this
General medical information about Dyazide
To reduce night time urination, take your last daily
dose of Dyazide before 6 p.m..
Take Dyazide with
food or milk to lessen stomach upset.
Do not use
salt substitutes or low-sodium milk products that contain
potassium while taking Dyazide. These products could cause
very high levels of potassium in your blood. Ask your doctor
or pharmacist about any salt substitutes you are taking.
Use caution when driving, operating machinery, or
performing other hazardous activities. Dyazide may cause
dizziness. If you experience dizziness, avoid these activities.
Who should not take Dyazide
Do not take Dyazide if you
- have an allergy
to sulfa-based drugs such as sulfa antibiotics,
have severe kidney disease,
- have high levels of
potassium in your blood (hyperkalemia); or
taking another diuretic that helps you retain potassium
such as spironolactone (Aldactone) or triamterene (Midamor).
Before taking this medication, tell your doctor if you have:
- liver disease,
- high levels of
triglycerides or cholesterol (types of fat) in your blood,
- kidney stones,
- gout, or
You may not be able to take Dyazide, or you may require
a lower dose or special monitoring during treatment if you
have any of the conditions listed above.
product is in the FDA pregnancy category C. This means that
it is not known whether Dyazide will harm an unborn baby.
Do not take this medication without first talking to your
doctor if you are pregnant.
Dyazide passes into breast
milk and may harm a nursing infant. Do not take this medication
without first talking to your doctor if you are breast-feeding
If you are 60 years of age, you may be more
likely to experience side effects from Dyazide. You may
require a lower dose of this medication.
How should take Dyazide Take Dyazide exactly as directed by your doctor.
If you do not understand these directions, ask your pharmacist,
nurse, or doctor to explain them to you.
It is usually
taken once a day but may be taken twice daily. Your doctor
will tell you how often you need to take it.
each dose with a full glass of water.
with food or milk to lessen stomach upset.
nighttime urination, take your last daily dose before 6
Dyazide should begin working about 4 to 6 hours
after you take it, but it may be a few weeks before you
see an improvement in your condition.
Do not stop
taking Dyazide suddenly even if you feel better. Stopping
suddenly could make your condition much worse.
Dyazide at room temperature away from moisture and heat.
If you miss a dose: If you take one dose daily, take the dose you missed
up to 12 hours late. If more than 12 hours have passed,
skip the missed dose and take only your next regularly scheduled
dose. Do not take a double dose of this medication unless
otherwise directed by your doctor.
If you take two
doses daily, take the dose you missed up to 6 hours late.
If more than 6 hours have passed, skip the missed dose and
take only your next regularly scheduled dose. Do not take
a double dose of this medication unless otherwise directed
by your doctor.
What happens if you overdose: Seek emergency medical treatment.
of a Dyazide overdose include very low blood pressure (fainting,
dizziness, confusion); an irregular heart beat; weakness;
nausea; vomiting; drowsiness; and unconsciousness.
Avoid while taking Dyazide Do not use salt substitutes or low-sodium milk products
that contain potassium while taking Dyazide. These products
could cause very high levels of potassium in your blood.
Ask your doctor or pharmacist about any salt substitutes
you are taking.
Avoid a diet high in salt. Too much
salt will cause your body to retain water and will decrease
the effects of Dyazide.
Avoid prolonged exposure
to sunlight. Hydrochlorothiazide may increase the sensitivity
of your skin to sunlight. Use a sunscreen and wear protective
clothing when exposure to the sun is unavoidable.
Use caution when driving, operating machinery, or performing
other hazardous activities. Dyazide may cause dizziness.
If you experience dizziness, avoid these activities.
Use alcohol cautiously. Alcohol may increase drowsiness
and dizziness while you are taking Dyazide.
becoming overheated during exercise and in hot weather.
This can lead to dehydration while taking Dyazide.
Tell your doctor and dentist that you are taking this medication
before having surgery.
Possible side effects of Dyazide If you experience any of the following serious side
effects, stop taking Dyazide and seek emergency medical
- an allergic reaction (difficulty breathing;
closing of your throat; swelling of your lips, tongue, or
face; or hives);
- irregular heartbeat, shortness
of breath, fatigue, confusion, weakness, numbness, or tingling,
caused by high levels of potassium in your blood; or
severe mood changes;
- muscle cramping;
black, bloody, or tarry stools;
- easy bruising or
- blood in your urine;
or no urine;
- yellowing of your skin or eyes; or
Other, less serious side effects
may be more likely to occur. Continue to take Dyazide and
talk to your doctor if you experience
- tingling or numbness in your hands or feet;
headache or tiredness;
- excessive urination;
muscle weakness or cramps;
- increased hunger or
- a dry mouth;
- nausea, vomiting,
diarrhea, or constipation;
- changes in weight;
- skin sensitivity to sunlight;
- decreased sex drive.
Side effects other
than those listed here may also occur. Talk to your doctor
about any side effect that seems unusual or that is especially
What other drugs will affect Dyazide Before taking this medication, tell your doctor if
you are taking any of the following medicines:
Angiotensin-converting-enzyme inhibitors (ACE inhibitors)
such as benazepril (Lotensin) or captopril (Capoten) may
increase potassium in your blood, which could be dangerous
when you are taking Dyazide.
- Other commonly used
ACE inhibitors include enalapril (Vasotec), fosinopril (Monopril),
lisinopril (Prinivil, Zestril), moexipril (Univasc), quinapril
(Accupril), and ramipril (Altace).
anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin,
Advil, Rufen, others), ketoprofen (Orudis, Orudis KT, Oruvail),
and naproxen (Naprosyn, Aleve, Anaprox) may decrease the
effects of Dyazide and may increase the risk of damage to
- Other commonly used NSAIDs include
diclofenac (Voltaren, Cataflam), etodolac (Lodine), fenoprofen
(Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin),
ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro),
piroxicam (Feldene), sulindac (Clinoril), and tolmetin (Tolectin).
- Diabetes medications such as chlorpropamide (Diabinese),
tolbutamide (Orinase), tolazamide (Tolinase), glipizide
(Glucotrol), and glyburide (Diabeta, Glynase, Micronase)
may not be as effective in lowering your blood sugar levels
when you are taking Dyazide. Your diabetes therapy may have
to be adjusted.
- Lithium (Lithobid, Lithane, Eskalith,
others) may have increased effects when taken with Dyazide
and may cause side effects.
- Steroid medications
such as hydrocortisone (Cortef, Hydrocortone, Solu-Cortef),
prednisone (Orasone, Deltasone, Meticorten), methylprednisolone
(Medrol, Depo-Medrol, A-MetaPred, Solu-Medrol, others),
prednisolone (Prelone, Delta Cortef, Pediapred, others),
dexamethasone (Decadron, Hexadrol), betamethasone (Celestone),
corticotropin (Acthar, ACTH), and others may affect potassium
levels in your blood.
- Warfarin (Coumadin) may have
decreased effects when it is taken with Dyazide.
Allopurinol (Zyloprim), probenecid (Benemid), and sulfinpyrazone
(Anturane) may have reduced effects because Dyazide increases
levels of uric acid in your body.
(Questran) and colestipol (Colestid) may decrease the effects
of Dyazide. Dyazide should be taken at least 1 hour before
or 4 hours after any dose of cholestyramine or colestipol.
- Laxatives may affect potassium levels in your body.
This could interfere with Dyazide therapy.
other than those listed here may also interact with Dyazide.
Talk to your doctor and pharmacist before taking any prescription
or over-the-counter medicines.