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Dyazide

What is Dyazide

Hydrochlorothiazide is a thiazide diuretic (water pill). It decreases the amount of fluid in your body by increasing the amount of salt and water you lose in your urine.

Triamterene is a potassium-sparing diuretic (also water pill). It is used to reduce the amount of fluid in the body without causing the loss of potassium.

Dyazide is used to treat edema (swelling) and hypertension (high blood pressure).

Dyazide may also be used for purposes other than those listed in this medication guide.

General medical information about Dyazide

To reduce night time urination, take your last daily dose of Dyazide before 6 p.m..

Take Dyazide with food or milk to lessen stomach upset.

Do not use salt substitutes or low-sodium milk products that contain potassium while taking Dyazide. These products could cause very high levels of potassium in your blood. Ask your doctor or pharmacist about any salt substitutes you are taking.

Use caution when driving, operating machinery, or performing other hazardous activities. Dyazide may cause dizziness. If you experience dizziness, avoid these activities.

Who should not take Dyazide

Do not take Dyazide if you
- have an allergy to sulfa-based drugs such as sulfa antibiotics,
- have severe kidney disease,
- have high levels of potassium in your blood (hyperkalemia); or
- are taking another diuretic that helps you retain potassium such as spironolactone (Aldactone) or triamterene (Midamor).

Before taking this medication, tell your doctor if you have:
- liver disease,
- high levels of triglycerides or cholesterol (types of fat) in your blood,
- kidney stones,
- gout, or
- diabetes.

You may not be able to take Dyazide, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

This combination product is in the FDA pregnancy category C. This means that it is not known whether Dyazide will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.

Dyazide passes into breast milk and may harm a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

If you are 60 years of age, you may be more likely to experience side effects from Dyazide. You may require a lower dose of this medication.

How should take Dyazide

Take Dyazide exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

It is usually taken once a day but may be taken twice daily. Your doctor will tell you how often you need to take it.

Take each dose with a full glass of water.

Take Dyazide with food or milk to lessen stomach upset.

To reduce nighttime urination, take your last daily dose before 6 p.m..

Dyazide should begin working about 4 to 6 hours after you take it, but it may be a few weeks before you see an improvement in your condition.

Do not stop taking Dyazide suddenly even if you feel better. Stopping suddenly could make your condition much worse.

Store Dyazide at room temperature away from moisture and heat.

If you miss a dose:

If you take one dose daily, take the dose you missed up to 12 hours late. If more than 12 hours have passed, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.

If you take two doses daily, take the dose you missed up to 6 hours late. If more than 6 hours have passed, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if you overdose:

Seek emergency medical treatment.

Symptoms of a Dyazide overdose include very low blood pressure (fainting, dizziness, confusion); an irregular heart beat; weakness; nausea; vomiting; drowsiness; and unconsciousness.

Avoid while taking Dyazide

Do not use salt substitutes or low-sodium milk products that contain potassium while taking Dyazide. These products could cause very high levels of potassium in your blood. Ask your doctor or pharmacist about any salt substitutes you are taking.

Avoid a diet high in salt. Too much salt will cause your body to retain water and will decrease the effects of Dyazide.

Avoid prolonged exposure to sunlight. Hydrochlorothiazide may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

Use caution when driving, operating machinery, or performing other hazardous activities. Dyazide may cause dizziness. If you experience dizziness, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking Dyazide.

Avoid becoming overheated during exercise and in hot weather. This can lead to dehydration while taking Dyazide.

Tell your doctor and dentist that you are taking this medication before having surgery.

Possible side effects of Dyazide

If you experience any of the following serious side effects, stop taking Dyazide and seek emergency medical treatment:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
- irregular heartbeat, shortness of breath, fatigue, confusion, weakness, numbness, or tingling, caused by high levels of potassium in your blood; or
- severe mood changes;
- muscle cramping;
- black, bloody, or tarry stools;
- easy bruising or bleeding;
- blood in your urine;
- little or no urine;
- yellowing of your skin or eyes; or
- confusion.

Other, less serious side effects may be more likely to occur. Continue to take Dyazide and talk to your doctor if you experience
- dizziness;
- tingling or numbness in your hands or feet;
- headache or tiredness;
- excessive urination;
- muscle weakness or cramps;
- increased hunger or thirst;
- a dry mouth;
- nausea, vomiting, diarrhea, or constipation;
- changes in weight;
- increased swelling;
- skin sensitivity to sunlight; or
- decreased sex drive.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Dyazide

Before taking this medication, tell your doctor if you are taking any of the following medicines:
- Angiotensin-converting-enzyme inhibitors (ACE inhibitors) such as benazepril (Lotensin) or captopril (Capoten) may increase potassium in your blood, which could be dangerous when you are taking Dyazide.
- Other commonly used ACE inhibitors include enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), quinapril (Accupril), and ramipril (Altace).
- Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Advil, Rufen, others), ketoprofen (Orudis, Orudis KT, Oruvail), and naproxen (Naprosyn, Aleve, Anaprox) may decrease the effects of Dyazide and may increase the risk of damage to your kidneys.
- Other commonly used NSAIDs include diclofenac (Voltaren, Cataflam), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), and tolmetin (Tolectin).
- Diabetes medications such as chlorpropamide (Diabinese), tolbutamide (Orinase), tolazamide (Tolinase), glipizide (Glucotrol), and glyburide (Diabeta, Glynase, Micronase) may not be as effective in lowering your blood sugar levels when you are taking Dyazide. Your diabetes therapy may have to be adjusted.
- Lithium (Lithobid, Lithane, Eskalith, others) may have increased effects when taken with Dyazide and may cause side effects.
- Steroid medications such as hydrocortisone (Cortef, Hydrocortone, Solu-Cortef), prednisone (Orasone, Deltasone, Meticorten), methylprednisolone (Medrol, Depo-Medrol, A-MetaPred, Solu-Medrol, others), prednisolone (Prelone, Delta Cortef, Pediapred, others), dexamethasone (Decadron, Hexadrol), betamethasone (Celestone), corticotropin (Acthar, ACTH), and others may affect potassium levels in your blood.
- Warfarin (Coumadin) may have decreased effects when it is taken with Dyazide.
- Allopurinol (Zyloprim), probenecid (Benemid), and sulfinpyrazone (Anturane) may have reduced effects because Dyazide increases levels of uric acid in your body.
- Cholestyramine (Questran) and colestipol (Colestid) may decrease the effects of Dyazide. Dyazide should be taken at least 1 hour before or 4 hours after any dose of cholestyramine or colestipol.
- Laxatives may affect potassium levels in your body. This could interfere with Dyazide therapy.

Drugs other than those listed here may also interact with Dyazide. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

All prescription drugs:

A
abilify accupril accutane acetaminophen aciphex actifed actonel actos acyclovir adalat adderall adipex advair advil albuterol alesse aleve allegra allopurinol amaryl ambien amiodarone amitriptyline amoxicillin amoxil amphetamine anacin aprazolam aricept asacol aspirin atenolol ativan atorvastatin atrovent augmentin avandia avapro avastin avelox azmacort
B
baclofen
bactrim bactroban baycol benadryl bextra biaxin boniva bontril buspar buspirone
C
caduet campral camptosar capoten captopril cardizem cardura carisoprodol casodex catapress cefzil celebrex celexa cellcept cephalexin cialis cipro ciprodex clarinex claritin climara clindamycin clonazepam clonidine codeine codeprex combivent combivir concerta copaxone coreg coricidin cotrim coumadin cozaar crestor cubicin cyclobenzaprine cymbalta
D
darvocet demerol depakote desogen detrol dextromethorphan diazepam diclofenac didrex diflucan digoxin dilantin diltiazem dimetapp diovan diprivan ditropan doxazosin doxycycline drixoral duragesic dyazide
E
effexor elavil elocon eloxatin emend enalapril enbrel endocet engerix-b entex epogen epzicom erbitux ertaczo ery-tab erythromycin estradiol evista 
F
fabrazyme famotidine fazaclo fenofibrate fioricet fiorinal flexeril flomax flonase flovent fluoxetine fosamax fosrenol furosemide  
G
gabapentin gamimune gemfibrozil gemzar glipizide glucophage glucotrol glucovance glyburide glyburide guaifenesin guaifenex 
H
herceptin humalog humira hydroxyzine hyzaar  
I
ibuprofen imdur imitrex imodium inderal insulin integrilin iressa 
K
kaletra keflex kenalog keppra ketek klonopin kytril  
L
lamictal lamisil lanoxin lantus lasix lescol levaquin levitra levothyroxine levoxyl lexapro lidoderm lipitor lisinopril lithium lorazepam lortab lotensin lotrel lotrisone lovenox lupron luveris  
M
macrobid magnevist meclizine medroxyprogesterone meridia metformin methadone methamphetamine methotrexate methylphenidate methylprednisolone metoclopramide metoprolol metronidazole miacalcin minocycline mobic monopril morphine motrin myfortic  
N
naproxen nasacort nasonex natrecor neulasta neupogen neurontin nexium nifedipine nitrofurantoin norco nortriptyline norvasc  
O
omeprazole omnicef orthovisc oxybutynin oxycodone oxycontin oxytrol  
P
paraplatin patanol paxil pegasys penicillin pepcid percocet percodan percogesic phendimetrazine phenergan phentermine phenytoin plavix plendil potassium pravachol prednisone premarin prempro prevacid prilosec prinivil procrit promethazine propecia propofol propoxyphene propranolol protonix proventil provigil prozac pseudoephedrine pulmicort  
R
ranitidine rebetol reglan relafen relpax remeron remicade renagel renova rhinocort riomet risperdal risperidone ritalin rituxan rocephin rogaine roxicet  
S
sanctura seasonale sensipar serevent seroquel serzone singulair skelaxin soma somavert sonata spiriva spironolactone strattera striant sustiva synagis synthroid 
T
tamoxifen tavist taxol taxotere tegretol temazepam tenormin tenuate tequin terazosin tetracycline tiazac tindamax titralac tobradex topamax toprol tramadol trazodone triamcinolone triaminic triamterene tricor trileptal trimox triphasil trizivir truvada tylenol 
U
ultane ultracet ultram uroxatral
V
valium valtrex vaniqa vasotec velcade verapamil viagra vicodin vicoprofen vidaza viracept viread vytorin  
W
warfarin wellbutrin  
X
xalatan xanax xenical xifaxan xolair xopenex xyrem  
Y
yasmin 
Z
zanaflex zantac zavesca zelnorm zemplar zerit zestoretic zestril zetia ziac zithromax zocor zofran zoladex zoloft zometa zorbtive zosyn zovirax zyrtec zyvox