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Enbrel

What is Enbrel

Enbrel reduces the actions of chemicals in the body that are involved in inflammatory and immune responses.

Enbrel is used to treat the symptoms of moderate to severe rheumatoid arthritis, polyarticular-course juvenile rheumatoid arthritis (JRA), and psoriatic arthritis.

Enbrel may also be used for purposes other than those listed in this medication guide.

General medical information about Enbrel

Do not use or handle this medication without first talking to your doctor if you have an allergy to latex. The needle cover is made from latex and you may have an allergic reaction to it.

In rare cases, Enbrel has caused serious blood problems. Notify your doctor immediately if you develop persistent fever, unexplained or prolonged bruising or bleeding, or pale skin. These symptoms may be signs of blood problems.

What you should find out before taking Enbrel

Do not use or handle this medication without first talking to your doctor if you have an allergy to latex. The needle cover is made from latex and you may have an allergic reaction to it.

Before using Enbrel, tell your doctor if you have:
- an allergy to benzyl alcohol;
- suppression of your immune system;
- a bone marrow disease;
- a demyelinating disorder such as multiple sclerosis, myelitis, or optic neuritis;
- seizures;
- any active infection or a history of recurrent infection;
- recently received a live vaccine; or
- poorly controlled diabetes.

You may not be able to use Enbrel, or you may require a dosage adjustment or special monitoring during your treatment.

Enbrel is in the FDA pregnancy category B. This means that it is not likely to harm an unborn baby. Do not use Enbrel without first talking to your doctor if you are pregnant.

It is not known whether Enbrel passes into breast milk. Do not use Enbrel without first talking to your doctor if you are breast-feeding.

The use of Enbrel by children younger than 4 years of age has not been studied.

How should you use Enbrel

Use Enbrel exactly as directed by your doctor. If you do not understand these directions, ask your doctor, nurse, or pharmacist to explain them to you.

Do not use or handle this medication without first talking to your doctor if you have an allergy to latex. The needle cover is made from latex and you may have an allergic reaction to it.

Enbrel is used as a subcutaneous (under the skin) injection only. Your doctor or nurse will give you detailed instructions on how and where to inject Enbrel. Do not inject this medication if you are unsure how.

Slowly mix the Enbrel with the supplied bacteriostatic water for injection. Some foaming may occur, this is normal. Gently swirl to dissolve, do not shake or vigorously agitate. Generally, it takes less than 10 minutes for the powder to dissolve completely.

The contents of one vial of Enbrel solution should not be mixed with or transferred into the contents of another vial of Enbrel. Do not add other medications to the Enbrel solution or mix the powder with any liquid other than the one provided.

Once the solution is mixed with the supplied bacteriostatic water for injection, use it as soon as possible. If you cannot inject it immediately, store it in the refrigerator at 36 to 46 degrees Fahrenheit (2 to 8 degrees Celsius) for up to 14 days. Do not allow the solution to freeze.

Injections can be given in the thigh, abdomen, or the back of the upper arm. It is important to rotate the site of injection with each dose to reduce the risk of injection site reactions or damage to the tissue. Do not inject this medication into any site that is red, painful, or hard.

Do not inject Enbrel if it is discolored, cloudy, or if it has particles in it.

Never reuse a needle or syringe. Dispose of all needles and syringes in an appropriate, puncture-resistant disposal container.

Store Enbrel in the refrigerator away from moisture and heat. Do not allow Enbrel to freeze.

If you miss a dose:

If you miss a dose and it is less than 48 hours since that dose was due, make up the missed injection as soon as you remember. However, if more than 48 hours have passed since the missed dose was due, do not make up that injection. Instead, simply wait until your next regularly scheduled dosing day and use the usual single dose.

What happens if you overdose:

Seek emergency medical attention or notify your doctor.

Symptoms of an Enbrel overdose are not known. No harmful effects due to large doses of Enbrel have been reported.

What should you avoid while using Enbrel

Do not receive any vaccination that involves the use of a live vaccine while using Enbrel, without first talking to your doctor. Enbrel may affect the immune system and a live vaccine could possibly result in an infection.

Possible side effects of Enbrel

In rare cases, Enbrel has caused serious blood problems. Notify your doctor immediately if you develop persistent fever, unexplained or prolonged bruising or bleeding, or pale skin. These symptoms may be signs of blood problems.

If you experience and of the following serious side effects, stop using Enbrel, and seek emergency medical attention or contact your doctor immediately:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- new or worsening neurologic symptoms such as worsening muscle pain, weakness or numbness; visual disturbances; seizures; or
- depression or other psychological changes.

Other less serious side effects may be more likely to occur. Continue to use Enbrel and notify your doctor if you experience
- a stuffy nose, a cough, a sore throat, a cold, fever, or other signs of infection;
- poor wound healing;
- an upset stomach, nausea, or vomiting;
- a headache;
- a rash; or
- redness, itching, pain, or swelling at the injection site.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Enbrel

Do not receive any vaccination that involves the use of a live vaccine while using Enbrel, without first talking to your doctor. Enbrel may affect your immune system and a live vaccine could possibly result in an infection.

It is not known if other drugs interact with Enbrel. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

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abilify accupril accutane acetaminophen aciphex actifed actonel actos acyclovir adalat adderall adipex advair advil albuterol alesse aleve allegra allopurinol amaryl ambien amiodarone amitriptyline amoxicillin amoxil amphetamine anacin aprazolam aricept asacol aspirin atenolol ativan atorvastatin atrovent augmentin avandia avapro avastin avelox azmacort
B
baclofen
bactrim bactroban baycol benadryl bextra biaxin boniva bontril buspar buspirone
C
caduet campral camptosar capoten captopril cardizem cardura carisoprodol casodex catapress cefzil celebrex celexa cellcept cephalexin cialis cipro ciprodex clarinex claritin climara clindamycin clonazepam clonidine codeine codeprex combivent combivir concerta copaxone coreg coricidin cotrim coumadin cozaar crestor cubicin cyclobenzaprine cymbalta
D
darvocet demerol depakote desogen detrol dextromethorphan diazepam diclofenac didrex diflucan digoxin dilantin diltiazem dimetapp diovan diprivan ditropan doxazosin doxycycline drixoral duragesic dyazide
E
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F
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G
gabapentin gamimune gemfibrozil gemzar glipizide glucophage glucotrol glucovance glyburide glyburide guaifenesin guaifenex 
H
herceptin humalog humira hydroxyzine hyzaar  
I
ibuprofen imdur imitrex imodium inderal insulin integrilin iressa 
K
kaletra keflex kenalog keppra ketek klonopin kytril  
L
lamictal lamisil lanoxin lantus lasix lescol levaquin levitra levothyroxine levoxyl lexapro lidoderm lipitor lisinopril lithium lorazepam lortab lotensin lotrel lotrisone lovenox lupron luveris  
M
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N
naproxen nasacort nasonex natrecor neulasta neupogen neurontin nexium nifedipine nitrofurantoin norco nortriptyline norvasc  
O
omeprazole omnicef orthovisc oxybutynin oxycodone oxycontin oxytrol  
P
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R
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S
sanctura seasonale sensipar serevent seroquel serzone singulair skelaxin soma somavert sonata spiriva spironolactone strattera striant sustiva synagis synthroid 
T
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U
ultane ultracet ultram uroxatral
V
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W
warfarin wellbutrin  
X
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Y
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