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Fabrazyme

What is Fabrazyme

Fabrazyme is a man-made form of the naturally-occurring enzyme a-galactosidase A. A deficiency of the enzyme a-galactosidase A is called Fabry disease. Fabrazyme reduces deposits of globotriaosylceramide (GL-3) in the kidneys and other certain other cells in the body.

Fabrazyme is used in the treatment of Fabry disease.

Fabrazyme may also be used for purposes other than those listed here.

General medical information about Fabrazyme

Symptoms of allergic or infusion reactions including difficulty breathing; closing of the throat; hives; rash; itching; fever; shaking; chest tightness; high or low blood pressure; fast heartbeats; muscle pain; stomach pain; nausea or vomiting; dizziness; numbness or tingling; and headache have occurred upon injection of Fabrazyme in many patients. Most patients treated with Fabrazyme develop antibodies to Fabrazyme and many will develop symptoms of an infusion reaction. A slow rate of injection of the medication and pretreatment with other medications may decrease the severity of these symptoms. Emergency medical attention may be required if a severe allergic reaction is experienced.

What you should discuss with your doctor before using Fabrazyme

Before using Fabrazyme, tell your doctor if you have:
- had an allergic reaction to Fabrazyme or have antibodies to the medication; or
- heart problems.

You may not be able to use Fabrazyme, or you may require a dosage adjustment or special monitoring during treatment.

Fabrazyme is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not use Fabrazyme without first talking to your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether Fabrazyme passes into breast milk. Do not use Fabrazyme without first talking to your doctor if you are breast-feeding a baby.

How should you use Fabrazyme

Use Fabrazyme exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Fabrazyme is given by intravenous (into the vein) injection and will most likely be administered by a healthcare provider.

Your doctor may want you to have blood tests or other medical evaluations during treatment with Fabrazyme to monitor progress and side effects.

Your healthcare provider will store Fabrazyme as instructed by the manufacturer. If you are storing Fabrazyme at home, your healthcare provider will give you instructions regarding how to store the medication.

If you miss a dose:

Contact your doctor if you miss a dose of Fabrazyme.

What happens if you overdose:

Contact your doctor, a hospital emergency room, or a poison control center if an overdose is suspected.

Although symptoms of an Fabrazyme overdose are not known, an overdose is unlikely to threaten life.

Avoid while taking Fabrazyme

There are no restrictions on food, beverages, or activity during treatment with Fabrazyme.

Possible side effects of Fabrazyme

Symptoms of allergic or infusion reactions including difficulty breathing; closing of the throat; hives; rash; itching; fever; shaking; chest tightness; high or low blood pressure; fast heartbeats; muscle pain; stomach pain; nausea or vomiting; dizziness; numbness or tingling; and headache have occurred upon injection of Fabrazyme in many patients. Most patients treated with Fabrazyme develop antibodies to Fabrazyme and many will develop symptoms of an infusion reaction. A slow rate of injection of the medication and pretreatment with other medications may decrease the severity of these symptoms. Emergency medical attention may be required if a severe allergic reaction is experienced.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Fabrazyme

Fabrazyme is not known to interact with other medications. Talk to your doctor or pharmacist before taking other prescription or over-the-counter medications, including herbal products, during treatment with Fabrazyme.

All prescription drugs:

A
abilify accupril accutane acetaminophen aciphex actifed actonel actos acyclovir adalat adderall adipex advair advil albuterol alesse aleve allegra allopurinol amaryl ambien amiodarone amitriptyline amoxicillin amoxil amphetamine anacin aprazolam aricept asacol aspirin atenolol ativan atorvastatin atrovent augmentin avandia avapro avastin avelox azmacort
B
baclofen
bactrim bactroban baycol benadryl bextra biaxin boniva bontril buspar buspirone
C
caduet campral camptosar capoten captopril cardizem cardura carisoprodol casodex catapress cefzil celebrex celexa cellcept cephalexin cialis cipro ciprodex clarinex claritin climara clindamycin clonazepam clonidine codeine codeprex combivent combivir concerta copaxone coreg coricidin cotrim coumadin cozaar crestor cubicin cyclobenzaprine cymbalta
D
darvocet demerol depakote desogen detrol dextromethorphan diazepam diclofenac didrex diflucan digoxin dilantin diltiazem dimetapp diovan diprivan ditropan doxazosin doxycycline drixoral duragesic dyazide
E
effexor elavil elocon eloxatin emend enalapril enbrel endocet engerix-b entex epogen epzicom erbitux ertaczo ery-tab erythromycin estradiol evista 
F
fabrazyme famotidine fazaclo fenofibrate fioricet fiorinal flexeril flomax flonase flovent fluoxetine fosamax fosrenol furosemide  
G
gabapentin gamimune gemfibrozil gemzar glipizide glucophage glucotrol glucovance glyburide glyburide guaifenesin guaifenex 
H
herceptin humalog humira hydroxyzine hyzaar  
I
ibuprofen imdur imitrex imodium inderal insulin integrilin iressa 
K
kaletra keflex kenalog keppra ketek klonopin kytril  
L
lamictal lamisil lanoxin lantus lasix lescol levaquin levitra levothyroxine levoxyl lexapro lidoderm lipitor lisinopril lithium lorazepam lortab lotensin lotrel lotrisone lovenox lupron luveris  
M
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N
naproxen nasacort nasonex natrecor neulasta neupogen neurontin nexium nifedipine nitrofurantoin norco nortriptyline norvasc  
O
omeprazole omnicef orthovisc oxybutynin oxycodone oxycontin oxytrol  
P
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R
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S
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T
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U
ultane ultracet ultram uroxatral
V
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W
warfarin wellbutrin  
X
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Y
yasmin 
Z
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