prescription drugs
Free drug information service 
All available medical information about prescription drugs 

Fluoxetine

What is fluoxetine

Fluoxetine is in a class of drugs called selective serotonin reuptake inhibitors. Fluoxetine affects chemicals in the brain that may become unbalanced and cause depression or mood disturbances, eating disorders, or obsessive or compulsive symptoms.

Fluoxetine is used to treat depression, obsessive-compulsive disorders, panic disorder, and bulimia (binge eating and purging). Fluoxetine is also used to treat premenstrual dysphoric disorder (PMDD), symptoms of which occur in the week or two before a woman's menstrual period and commonly include irritability, mood swings, and tension as well as the physical symptoms of bloating and breast tenderness.

Fluoxetine may also be used for purposes other than those listed in this medication guide.

General medical information about fluoxetine

Do not stop taking fluoxetine without first talking to your doctor. It may take several weeks before you to start feeling better.

What you should find out before taking fluoxetine

Do not take fluoxetine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) during the last 2 weeks. Serious, and sometimes fatal, reactions have occurred when these medicines have been used together. Also, do not take fluoxetine if you are taking thioridazine (Mellaril). Dangerous, even fatal irregular heartbeats may occur if these medicines are taken together. You must wait 5 weeks after stopping fluoxetine before taking thioridazine (Mellaril).

Before taking fluoxetine, tell your doctor if you
- have liver disease;
- have kidney disease;
- have diabetes;
- suffer from seizures; or
- suffer from mania or have suicidal thoughts.

You may not be able to take fluoxetine, or you may need a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Fluoxetine is in the FDA pregnancy category C. This means that it is not known whether fluoxetine will be harmful to an unborn baby. Do not take fluoxetine without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Fluoxetine passes into breast milk and may affect a nursing infant. Do not take fluoxetine without first talking to your doctor if you are breast-feeding a baby.

How should take fluoxetine

Take fluoxetine exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with water.

To ensure that you get the correct dose, measure the oral solution with a dose-measuring cup or spoon, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Fluoxetine may be taken with or without food.

Try to take fluoxetine at the same time each day.

Take Prozac Weekly on the same day each week as directed by your doctor.

Do not stop taking fluoxetine without first talking to your doctor. It may take several weeks before you to start feeling better.

Your doctor may want to perform tests or schedule appointments to monitor your treatment with fluoxetine.

Store fluoxetine at room temperature away from moisture and heat.

If you miss a dose:

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if you overdose:

Seek emergency medical attention.

Symptoms of a fluoxetine overdose include nausea, vomiting, tremor, agitation, seizures, drowsiness, hyperactivity, and enlarged pupils.

Avoid while taking fluoxetine

Use caution when driving, operating machinery, or performing other hazardous activities. Fluoxetine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness or dizziness while taking fluoxetine.

Possible side effects of fluoxetine

If you experience any of the following serious side effects, stop taking fluoxetine and contact your doctor immediately or seek emergency medical treatment:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- an irregular heartbeat or pulse;
- low blood pressure (dizziness, weakness);
- high blood pressure (severe headache, blurred vision);
- chills or fever;
- unusual bleeding or bruising;
- a rash or hives.

If you experience any of the following less serious side effects, continue taking fluoxetine and talk to your doctor:
- headache, tremor, nervousness, or anxiety;
- difficulty concentrating;
- nausea, diarrhea, dry mouth, or changes in appetite or weight;
- weakness;
- increased sweating;
- sleepiness or insomnia; or
- decreased sex drive, impotence, or difficulty having an orgasm.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect fluoxetine

Do not take fluoxetine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) during the last 2 weeks. Serious, and sometimes fatal, reactions have occurred when these medicines have been used together. Also, do not take fluoxetine if you are taking thioridazine (Mellaril). Dangerous, even fatal irregular heartbeats may occur if these medicines are taken together. You must wait 5 weeks after stopping fluoxetine before taking thioridazine (Mellaril).

Before taking fluoxetine, tell your doctor if you are taking any of the following medicines:
- a benzodiazepine such as diazepam (Valium), alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), temazepam (Restoril), triazolam (Halcion), and others;
- a tricyclic antidepressant such as amitriptyline (Elavil), imipramine (Tofranil), doxepin (Sinequan), nortriptyline (Pamelor), and others;
- St. John's wort;
- a phenothiazine such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), and others;
- lithium (Lithobid, Eskalith, others) or haloperidol (Haldol);
- almotriptan (Axert), frovatriptan (Frova), sumatriptan (Imitrex), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig);
- carbamazepine (Tegretol) or phenytoin (Dilantin);
- warfarin (Coumadin); or
- digoxin (Lanoxin).

You may not be able to take fluoxetine, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with fluoxetine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

All prescription drugs:

A
abilify accupril accutane acetaminophen aciphex actifed actonel actos acyclovir adalat adderall adipex advair advil albuterol alesse aleve allegra allopurinol amaryl ambien amiodarone amitriptyline amoxicillin amoxil amphetamine anacin aprazolam aricept asacol aspirin atenolol ativan atorvastatin atrovent augmentin avandia avapro avastin avelox azmacort
B
baclofen
bactrim bactroban baycol benadryl bextra biaxin boniva bontril buspar buspirone
C
caduet campral camptosar capoten captopril cardizem cardura carisoprodol casodex catapress cefzil celebrex celexa cellcept cephalexin cialis cipro ciprodex clarinex claritin climara clindamycin clonazepam clonidine codeine codeprex combivent combivir concerta copaxone coreg coricidin cotrim coumadin cozaar crestor cubicin cyclobenzaprine cymbalta
D
darvocet demerol depakote desogen detrol dextromethorphan diazepam diclofenac didrex diflucan digoxin dilantin diltiazem dimetapp diovan diprivan ditropan doxazosin doxycycline drixoral duragesic dyazide
E
effexor elavil elocon eloxatin emend enalapril enbrel endocet engerix-b entex epogen epzicom erbitux ertaczo ery-tab erythromycin estradiol evista 
F
fabrazyme famotidine fazaclo fenofibrate fioricet fiorinal flexeril flomax flonase flovent fluoxetine fosamax fosrenol furosemide  
G
gabapentin gamimune gemfibrozil gemzar glipizide glucophage glucotrol glucovance glyburide glyburide guaifenesin guaifenex 
H
herceptin humalog humira hydroxyzine hyzaar  
I
ibuprofen imdur imitrex imodium inderal insulin integrilin iressa 
K
kaletra keflex kenalog keppra ketek klonopin kytril  
L
lamictal lamisil lanoxin lantus lasix lescol levaquin levitra levothyroxine levoxyl lexapro lidoderm lipitor lisinopril lithium lorazepam lortab lotensin lotrel lotrisone lovenox lupron luveris  
M
macrobid magnevist meclizine medroxyprogesterone meridia metformin methadone methamphetamine methotrexate methylphenidate methylprednisolone metoclopramide metoprolol metronidazole miacalcin minocycline mobic monopril morphine motrin myfortic  
N
naproxen nasacort nasonex natrecor neulasta neupogen neurontin nexium nifedipine nitrofurantoin norco nortriptyline norvasc  
O
omeprazole omnicef orthovisc oxybutynin oxycodone oxycontin oxytrol  
P
paraplatin patanol paxil pegasys penicillin pepcid percocet percodan percogesic phendimetrazine phenergan phentermine phenytoin plavix plendil potassium pravachol prednisone premarin prempro prevacid prilosec prinivil procrit promethazine propecia propofol propoxyphene propranolol protonix proventil provigil prozac pseudoephedrine pulmicort  
R
ranitidine rebetol reglan relafen relpax remeron remicade renagel renova rhinocort riomet risperdal risperidone ritalin rituxan rocephin rogaine roxicet  
S
sanctura seasonale sensipar serevent seroquel serzone singulair skelaxin soma somavert sonata spiriva spironolactone strattera striant sustiva synagis synthroid 
T
tamoxifen tavist taxol taxotere tegretol temazepam tenormin tenuate tequin terazosin tetracycline tiazac tindamax titralac tobradex topamax toprol tramadol trazodone triamcinolone triaminic triamterene tricor trileptal trimox triphasil trizivir truvada tylenol 
U
ultane ultracet ultram uroxatral
V
valium valtrex vaniqa vasotec velcade verapamil viagra vicodin vicoprofen vidaza viracept viread vytorin  
W
warfarin wellbutrin  
X
xalatan xanax xenical xifaxan xolair xopenex xyrem  
Y
yasmin 
Z
zanaflex zantac zavesca zelnorm zemplar zerit zestoretic zestril zetia ziac zithromax zocor zofran zoladex zoloft zometa zorbtive zosyn zovirax zyrtec zyvox