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Glyburide

What is glyburide

Glyburide is in a class of drugs called sulfonylureas. It is used to help control blood sugar levels.

Glyburide is used to treat noninsulin-dependent (Type II) diabetes mellitus (NIDDM) along with diet, exercise, and insulin therapy, if necessary.

Glyburide may also be used for purposes other than those listed in this medication guide.

General medical information about glyburide

Treatment with glyburide may increase the risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin. Discuss with your doctor the risks and benefits of treatment with glyburide.

Know the signs and symptoms of low blood sugar (hypoglycemia), which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. Carry a piece of hard candy or glucose tablets with you to treat episodes of low blood sugar.

Follow diet, medication, and exercise routines closely. Changing any of them can affect your blood sugar levels.

Do not change your dose of glyburide without first talking to your doctor.

Avoid alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

What you should find out before taking glyburide

Before taking glyburide, tell your doctor if you
- have kidney disease;
- have liver disease;
- have thyroid disease;
- have Type 1 diabetes mellitus (insulin-dependent diabetes);
- have a serious infection, illness, or injury; or
- need surgery.

You may not be able to take glyburide, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Glyburide is in the FDA pregnancy category C. This means that it is not known whether glyburide will be harmful to an unborn baby. Insulin is usually the drug of choice for controlling diabetes during pregnancy. Do not take glyburide without first talking to your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether glyburide passes into breast milk. Do not take glyburide without first talking to your doctor if you are breast-feeding a baby.

How should take glyburide

Take glyburide exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Glyburide is usually taken before breakfast if it is taken once a day, or before meals if it is taken multiple times each day. Follow your doctor's instructions.

Glyburide begins to work in approximately 1 hour and will continue working for about 24 hours.

Do not change your dose of glyburide without first talking to your doctor.

Store glyburide at room temperature away from moisture and heat.

If you miss a dose:

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if you overdose:

Seek emergency medical attention.

Symptoms of a glyburide overdose include hunger, nausea, anxiety, cold sweats, weakness, drowsiness, unconsciousness, and coma.

Avoid while taking glyburide

Follow diet, medication, and exercise routines closely. Changing any of these things can effect your blood sugar levels.

Avoid alcohol. It lowers blood sugar and may interfere with your diabetes treatment.

Tell your doctor and dentist that you are taking this medication before you undergo any surgery.

Do not take any over-the-counter cough, cold, allergy, pain, or weight loss medications without first talking to your doctor.

Possible side effects of glyburide

Stop taking glyburide and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives).

Other, less serious side effects from glyburide result mostly from blood sugar levels that are either too high or too low. You should be familiar with the symptoms of both high and low blood sugar levels and know how to treat both conditions. Also, be sure your family and close friends know how to help you in an emergency situation.

Low blood sugar may occur when too much glyburide is taken; when meals are missed or delayed; if you exercise more than usual; during illness, especially with vomiting or diarrhea; if you take other medications; after drinking alcohol; and in other situations.

Hypoglycemia or Low blood sugar has the following symptoms:
- shaking;
- headache;
- cold sweats;
- pale, cool skin;
- anxiety; and
- difficulty concentrating.

Keep hard, sugary candy; chocolate; fruit juice; or glucose tablets on hand to treat episodes of low blood sugar.

Increased blood sugar may occur when not enough glyburide is taken; if you eat significantly more food then usual; if you exercise less than usual; if you take other medications; during fever or other illness; and in other situations.

Hyperglycemia or High blood sugar has the following symptoms:
- increased thirst,
- increased hunger, and
- increased urination.

There may be an increased risk of death due to cardiovascular (heart and blood vessels) complications with the use of glyburide when compared to the treatment of diabetes with diet or diet plus insulin. The long-term use of glyburide should be discussed with your doctor.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect glyburide

Many other medicines may increase or decrease the effects of glyburide or affect your condition. Before taking glyburide, tell your doctor if you are taking any of the following medicines:
- aspirin or another salicylate such as magnesium/choline salicylate (Trilisate), salsalate (Disalcid, others), choline salicylate (Arthropan), magnesium salicylate (Magan), or bismuth subsalicylate (Pepto-Bismol);
- a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis KT, Oruvail), diclofenac (Voltaren, Cataflam), etodolac (Lodine), indomethacin (Indocin), nabumetone (Relafen), oxaprozin (Daypro), naproxen (Anaprox, Naprosyn, Aleve), and others;
- a sulfa-based drug such as sulfamethoxazole-trimethoprim (Bactrim, Septra), sulfisoxazole (Gantrisin), or sulfasalazine (Azulfidine);
- a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil);
- a beta-blocker such as propranolol (Inderal), atenolol (Tenormin), acebutolol (Sectral), metoprolol (Lopressor), and others;
- a diuretic (water pill) such as hydrochlorothiazide (HCTZ, Hydrodiuril), chlorothiazide (Diuril), and others;
- a steroid medicine such as prednisone (Deltasone, Orasone, others), methylprednisolone (Medrol, others), prednisolone (Prelone, Pediapred, others), and others;
- a phenothiazine such as chlorpromazine (Thorazine), fluphenazine (Prolixin, Permitil), prochlorperazine (Compazine), promethazine (Phenergan), and others;
- phenytoin (Dilantin);
- isoniazid (Nydrazid); or
- prescription, over-the-counter, or herbal cough, cold, allergy, or weight loss medications.

You may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with glyburide or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

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