prescription drugs
Free drug information service 
All available medical information about prescription drugs 


What is ibuprofen

Ibuprofen is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Ibuprofen is used to reduce the fever, pain, inflammation, and stiffness caused by many conditions, such as osteoarthritis, rheumatoid arthritis, and abdominal cramps associated with menstruation.

Ibuprofen may also be used for purposes other than those listed in this medication guide.

General medical information about ibuprofen

Take ibuprofen with food, milk, or an antacid to lessen stomach upset.

Contact your doctor if you experience bloody, black, or tarry stools or blood in the vomit. These symptoms could indicate damage to the gastrointestinal tract.

If you drink more than three alcoholic beverages a day, ibuprofen may increase the risk of stomach bleeding.

What you should find out before taking ibuprofen

Before taking ibuprofen, tell your doctor if you
- have an allergy to aspirin or any other NSAIDs,
- have an ulcer or bleeding in the stomach,
- drink more than three alcoholic beverages a day,
- have liver or kidney disease,
- have a coagulation (bleeding or blood clotting) disorder,
- have congestive heart failure,
- have fluid retention,
- have heart disease, or
- have high blood pressure.

You may not be able to take ibuprofen, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether ibuprofen will be harmful to an unborn baby. Ibuprofen should not be taken late in pregnancy (the third trimester) because a similar drug is known to affect the baby's heart. Do not take ibuprofen without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Ibuprofen passes into breast milk in very small amounts, however it is not expected to be harmful to a nursing baby. Talk to your doctor before taking ibuprofen if you are breast-feeding.

How should take ibuprofen

Take ibuprofen exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you

Take each dose with a full glass of water.

Take ibuprofen with food, milk, or an antacid to lessen stomach upset.

Store ibuprofen at room temperature away from moisture and heat.

If you miss a dose:

Take the missed dose as soon as you remember up to 2 hours late. If more than 2 hours have passed since the missed dose, skip it and take only the next regularly scheduled dose. Do not take a double dose.

What happens if you overdose:

Seek emergency medical attention if an overdose is suspected.

Symptoms of a ibuprofen overdose include nausea, vomiting or stomach pain, dizziness, drowsiness, headache, ringing in the ears, blurred vision, seizures, sweating, numbness or tingling, little or no urine production, and slow breathing.

Avoid while taking ibuprofen

Avoid prolonged exposure to sunlight. Ibuprofen may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

If you drink more than three alcoholic beverages a day, ibuprofen may increase the risk of stomach bleeding.

Possible side effects of ibuprofen

If you experience any of the following serious side effects, stop taking ibuprofen and seek medical treatment or contact your doctor immediately:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- muscle cramps, numbness, or tingling;
- ulcers (open sores) in the mouth;
- rapid weight gain (fluid retention);
- seizures;
- black, bloody, or tarry stools;
- blood in your urine or vomit;
- decreased hearing or ringing in the ears;
- jaundice (yellowing of the skin or eyes); or
- abdominal cramping, indigestion, or heartburn.

Other, less serious side effects may be more likely to occur. Continue to take ibuprofen and talk to your doctor if you experience
- dizziness or headache;
- nausea, gaseousness, diarrhea, or constipation;
- depression;
- fatigue or weakness;
- dry mouth; or
- irregular menstrual periods.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect ibuprofen

Other prescription and over-the-counter drugs may interact with ibuprofen. Talk to your doctor before taking ibuprofen if you are taking any of the following drugs:
- another nonsteroidal anti-inflammatory drug (NSAID) such as ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Aleve, Anaprox), diclofenac (Voltaren, Cataflam), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin);
- aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), choline salicylate, and magnesium salicylate;
- a diuretic (water pill) such as hydrochlorothiazide (HCTZ, HydroDiuril, others), chlorothiazide (Diuril, others), chlorthalidone (Thalitone), bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix), spironolactone (Aldactone), and amiloride (Midamor);
- an anticoagulant such as warfarin (Coumadin);
- a steroid such as prednisone (Deltasone);
- an oral diabetes medication such as glipizide (Glucotrol) or glyburide (Micronase, Diabeta); or
- lithium (Eskalith, Lithobid, others).

Talk to your doctor before taking ibuprofen if you are taking any other medicines, especially any of the ones listed above.

Drugs other than those listed here may also interact with ibuprofen. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

All prescription drugs:

abilify accupril accutane acetaminophen aciphex actifed actonel actos acyclovir adalat adderall adipex advair advil albuterol alesse aleve allegra allopurinol amaryl ambien amiodarone amitriptyline amoxicillin amoxil amphetamine anacin aprazolam aricept asacol aspirin atenolol ativan atorvastatin atrovent augmentin avandia avapro avastin avelox azmacort
bactrim bactroban baycol benadryl bextra biaxin boniva bontril buspar buspirone
caduet campral camptosar capoten captopril cardizem cardura carisoprodol casodex catapress cefzil celebrex celexa cellcept cephalexin cialis cipro ciprodex clarinex claritin climara clindamycin clonazepam clonidine codeine codeprex combivent combivir concerta copaxone coreg coricidin cotrim coumadin cozaar crestor cubicin cyclobenzaprine cymbalta
darvocet demerol depakote desogen detrol dextromethorphan diazepam diclofenac didrex diflucan digoxin dilantin diltiazem dimetapp diovan diprivan ditropan doxazosin doxycycline drixoral duragesic dyazide
effexor elavil elocon eloxatin emend enalapril enbrel endocet engerix-b entex epogen epzicom erbitux ertaczo ery-tab erythromycin estradiol evista 
fabrazyme famotidine fazaclo fenofibrate fioricet fiorinal flexeril flomax flonase flovent fluoxetine fosamax fosrenol furosemide  
gabapentin gamimune gemfibrozil gemzar glipizide glucophage glucotrol glucovance glyburide glyburide guaifenesin guaifenex 
herceptin humalog humira hydroxyzine hyzaar  
ibuprofen imdur imitrex imodium inderal insulin integrilin iressa 
kaletra keflex kenalog keppra ketek klonopin kytril  
lamictal lamisil lanoxin lantus lasix lescol levaquin levitra levothyroxine levoxyl lexapro lidoderm lipitor lisinopril lithium lorazepam lortab lotensin lotrel lotrisone lovenox lupron luveris  
macrobid magnevist meclizine medroxyprogesterone meridia metformin methadone methamphetamine methotrexate methylphenidate methylprednisolone metoclopramide metoprolol metronidazole miacalcin minocycline mobic monopril morphine motrin myfortic  
naproxen nasacort nasonex natrecor neulasta neupogen neurontin nexium nifedipine nitrofurantoin norco nortriptyline norvasc  
omeprazole omnicef orthovisc oxybutynin oxycodone oxycontin oxytrol  
paraplatin patanol paxil pegasys penicillin pepcid percocet percodan percogesic phendimetrazine phenergan phentermine phenytoin plavix plendil potassium pravachol prednisone premarin prempro prevacid prilosec prinivil procrit promethazine propecia propofol propoxyphene propranolol protonix proventil provigil prozac pseudoephedrine pulmicort  
ranitidine rebetol reglan relafen relpax remeron remicade renagel renova rhinocort riomet risperdal risperidone ritalin rituxan rocephin rogaine roxicet  
sanctura seasonale sensipar serevent seroquel serzone singulair skelaxin soma somavert sonata spiriva spironolactone strattera striant sustiva synagis synthroid 
tamoxifen tavist taxol taxotere tegretol temazepam tenormin tenuate tequin terazosin tetracycline tiazac tindamax titralac tobradex topamax toprol tramadol trazodone triamcinolone triaminic triamterene tricor trileptal trimox triphasil trizivir truvada tylenol 
ultane ultracet ultram uroxatral
valium valtrex vaniqa vasotec velcade verapamil viagra vicodin vicoprofen vidaza viracept viread vytorin  
warfarin wellbutrin  
xalatan xanax xenical xifaxan xolair xopenex xyrem  
zanaflex zantac zavesca zelnorm zemplar zerit zestoretic zestril zetia ziac zithromax zocor zofran zoladex zoloft zometa zorbtive zosyn zovirax zyrtec zyvox