What you should find out before taking
not take metoclopramide if you have
- bleeding, an injury, or an obstruction in your stomach;
- pheochromocytoma; or
- epilepsy or another seizure disorder.
conditions make it dangerous to use metoclopramide.
taking this medication, tell your doctor if you have:
- kidney disease;
- a history of depression;
- Parkinson's disease;
- high blood pressure; or
- recently had stomach surgery.
may not be able to take metoclopramide, or you may require
a dosage adjustment or special monitoring during treatment
if you have any of the conditions listed above.
is in the FDA pregnancy category B. This means that it is
unlikely to harm an unborn baby. Do not take metoclopramide
without first talking to your doctor if you are pregnant.
passes into breast milk. Do not take metoclopramide without
first talking to your doctor if you are breast-feeding a baby.
What is metoclopramide
Metoclopramide increases the rate at which the stomach
and intestines move during digestion. It also increases
the rate at which the stomach empties into the intestines
and increases the strength of the lower esophageal sphincter
(the muscle between the stomach and esophagus).
is used to treat diabetic gastric stasis (slow movement
of the stomach), which causes symptoms such as nausea, vomiting,
heartburn, decreased appetite, and prolonged fullness after
eating. It is also used to treat gastric reflux or heartburn
(the regurgitation of stomach acid into the esophagus),
prevention of postoperative nausea and vomiting, prevention
of nausea and vomiting associated with cancer chemotherapy,
facilitation of small bowel intubation, and to facilitate
x-ray examination of the stomach and intestines.
Metoclopramide may also be used for purposes other than
those listed in this medication guide.
How should take metoclopramide
Take metoclopramide exactly as directed by your doctor.
If you do not understand these directions, ask your pharmacist,
nurse, or doctor to explain them to you.
dose with a full glass of water.
To ensure that you
get a correct dose, measure the liquid form of metoclopramide
with a special dose-measuring spoon or cup, not with a regular
table spoon. If you do not have a dose-measuring device,
ask your pharmacist where you can get one.
is available as both a syrup and a concentrated solution.
Although the dose remains the same, the amount of liquid
needed to make a dose is different. Follow your doctor's
Metoclopramide is usually taken four
times a day, 30 minutes before meals and at bedtime. Follow
your doctor's instructions.
at room temperature away from moisture and heat.
If you miss a dose: Take the missed dose as soon as you remember. However,
if it is almost time for your next dose, skip the missed
dose and take only your next regularly scheduled dose. Do
not take a double dose of this medication.
What happens if you overdose: Seek emergency medical attention.
of a metoclopramide overdose include drowsiness; confusion;
uncontrollable movements of the arms, legs, face, or tongue;
muscle spasm of the neck; tremor; irritability; and agitation.
Avoid while taking metoclopramide Use caution when driving, operating machinery, or
performing other hazardous activities. Metoclopramide may
cause drowsiness. If you experience drowsiness, avoid these
Possible side effects of metoclopramide If you experience any of the following serious side
effects, stop taking metoclopramide and seek emergency medical
attention or contact your doctor immediately:
allergic reaction (difficulty breathing; closing of your
throat; swelling of your lips, tongue, or face; or hives);
- uncontrollable movements or spasms of your arms,
legs, lips, jaw, tongue, face, or other body part;
anxiety, agitation, jitteriness, difficulty breathing, or
- yellowing of the
skin or eyes;
- changes in vision;
- an irregular
- seizures or hallucinations.
Other, less serious side effects may be more likely to occur.
Continue to take metoclopramide and talk to your doctor
if you experience
- nausea or diarrhea;
dizziness, drowsiness, or headache;
- fluid retention (swelling of hands or legs, bloating);
- breast tenderness or swelling;
in your menstrual cycle; or
- increased frequency
Side effects other than those listed
here may also occur. Talk to your doctor about any side
effect that seems unusual or that is especially bothersome.
What other drugs will affect metoclopramide Tell your doctor if you have taken a monoamine oxidase
inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine
(Parnate), or phenelzine (Nardil) in the last 14 days. Metoclopramide
must be used very cautiously if you are taking any of these
Before taking metoclopramide, tell your
doctor if you are taking any of the following medicines:
- digoxin (Lanoxin, Lanoxicaps);
- tetracycline (Sumycin, others);
- levodopa (Larodopa, Dopar, Sinemet);
- a narcotic pain reliever such as morphine (MS Contin,
MSIR, others), codeine, hydrocodone (Vicodin, Hycodan),
oxycodone (Percocet, Percodan, Tylox, OxyContin), oxymorphone
(Numorphan), and others; or
- clidinium (Quarzan),
dicyclomine (Bentyl), hyoscyamine (Levsin, Cystospaz, Anaspaz),
belladonna (Donnatal), or propantheline (Pro-Banthine).
You may not be able to take metoclopramide, or you
may require a dosage adjustment or special monitoring if
you are taking any of the medicines listed above.
Metoclopramide may increase the effects of other drugs that
cause drowsiness, including antidepressants, alcohol, antihistamines,
sedatives (used to treat insomnia), pain relievers, anxiety
medicines, and muscle relaxants. Tell your doctor about
all medicines that you are taking, and do not take any medicine
unless your doctor approves.
other than those listed here may also interact with metoclopramide.
Talk to your doctor and pharmacist before taking any prescription
or over-the-counter medicines.