What is Promethazine
is an antihistamine. It blocks the effects of the naturally
occurring chemical histamine in your body.
is used to treat allergic symptoms and reactions such as itching,
runny nose; sneezing; itchy, watery eyes; hives; and itchy
is also used to cause sedation (sleep), to assist in controlling
postoperative pain, to control nausea and vomiting (especially
after surgery), and to prevent motion sickness.
may also be used for purposes other than those listed in this
General medical information about Promethazine
Call your doctor immediately if you experience uncontrollable
movements of your eyes, lips, tongue, face, arms, or legs.
These could be early signs of dangerous side effects.
Use caution when driving, operating machinery, or performing
other hazardous activities. Promethazine may cause dizziness
or drowsiness. If you experience dizziness or drowsiness,
avoid these activities.
Use alcohol cautiously. Alcohol
may increase drowsiness and dizziness while you are taking
Who should not take Promethazine
Before taking Promethazine, tell your doctor if you have:
- epilepsy or another seizure disorder;
been diagnosed with sleep apnea (periods of not breathing
- an ulcer or an
obstruction in your stomach;
- bladder problems or
- high blood pressure or any
type of heart disease; or
- liver problems.
You may not be able to take Promethazine, or you may require
a lower dose or special monitoring during treatment if you
have any of the conditions listed above.
is in the FDA pregnancy category C. This means that it is
not known whether Promethazine will harm an unborn baby.
Do not take Promethazine without first talking to your doctor
if you are pregnant or if you are planning a pregnancy.
It is not known whether Promethazine passes into
breast milk. Do not take Promethazine without first talking
to your doctor if you are breast-feeding a baby.
If you are over 60 years of age, you may be more likely
to experience side effects from Promethazine. You may require
a lower dose of this medication.
The safety of Promethazine
has not been established for children younger than 2 years
How should take Promethazine Take Promethazine exactly as directed by your doctor.
If you do not understand the directions on your prescription
bottle, ask your pharmacist, nurse, or doctor to explain
the instructions to you.
Take each oral dose with
a full glass of water.
You can take Promethazine
with or without food.
To ensure that you get a correct
dose, measure the syrup form of Promethazine with a special
dose-measuring spoon or cup, not with a regular tablespoon.
If you do not have a dose-measuring device, ask your pharmacist
where you can get one.
The suppositories are for
rectal use only. Ask your doctor, nurse, or pharmacist to
explain how to use a suppository if you do not know how.
Store Promethazine at room temperature away from
moisture and heat.
Store the suppositories in the
If you miss a dose: Take the missed dose as soon as you remember. However,
if it is almost time for your next dose, skip the missed
dose and take only your next regularly scheduled dose. Do
not take a double dose of this medication unless otherwise
directed by your doctor.
What happens if you overdose: Seek emergency medical attention.
of a Promethazine overdose include severe drowsiness, dizziness,
dry mouth, large pupils, flushing, nausea, vomiting, difficulty
breathing, and unconsciousness.
Avoid while taking Promethazine Use caution when driving, operating machinery, or
performing other hazardous activities. Promethazine may
cause dizziness or drowsiness. If you experience dizziness
or drowsiness, avoid these activities.
cautiously. Alcohol may increase drowsiness and dizziness
while you are taking Promethazine.
exposure to sunlight. Promethazine may increase the sensitivity
of your skin to sunlight. Use a sunscreen and wear protective
clothing when exposure to the sun is unavoidable.
Possible side effects of Promethazine If you experience any of the following serious side
effects, stop taking Promethazine and seek emergency medical
- an allergic reaction (difficulty breathing;
closing of your throat; swelling of your lips, tongue, or
face; or hives);
- uncontrollable movements of your
eyes, lips, tongue, face, arms, or legs; or
of your skin or eyes, abdominal pain.
serious side effects may be more likely to occur. Continue
to take Promethazine and talk to your doctor if you experience
- dizziness, drowsiness, sleepiness, or confusion;
- blurred vision or a dry mouth;
or vomiting; or
- increased sensitivity to sunlight.
Side effects other than those listed here may also
occur. Talk to your doctor about any side effect that seems
unusual or that is especially bothersome.
What other drugs will affect Promethazine Before taking this medication, tell your doctor if
you are taking any of the following medicines:
anxiety or sleep medicines such as alprazolam (Xanax), diazepam
(Valium), chlordiazepoxide (Librium), temazepam (Restoril),
or triazolam (Halcion);
- medications for depression
such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline
(Pamelor), fluoxetine (Prozac), sertraline (Zoloft), or
- narcotics (pain killers) such
as: meperidine (Demerol), morphine (MS Contin, MSIR, others),
propoxyphene (Darvon, Darvocet), hydrocodone (Lorcet, Vicodin),
oxycodone (Percocet, Percodan), fentanyl (Duragesic), and
codeine (Fiorinal, Fioricet, Tylenol #3, others);
other sedatives such as phenobarbital (Solfoton, Luminal),
amobarbital (Amytal) and secobarbital (Seconal); or
any other medications that make you feel drowsy, sleepy,
other than those listed here may also interact with Promethazine.
Talk to your doctor and pharmacist before taking any prescription
or over-the-counter medicines.