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Serzone

What is Serzone

Serzone is an antidepressant medication. It affects chemicals in the brain that may become unbalanced and cause depression.

Serzone is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide.

Serzone may also be used for purposes other than those listed in this medication guide.

General medical information about Serzone

Do not take Serzone if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days, or if you are taking terfenadine (Seldane, Seldane-D), astemizole (Hismanal), cisapride (Propulsid), pimozide (Orap), triazolam (Halcion), or carbamazepine (Tegretol, Tegretol XR, Epitol, Carbatrol).

In rare cases, treatment with Serzone has been associated with serious liver problems, sometimes resulting in liver transplant or death. Contact your doctor immediately if you experience yellowing of the skin or eyes; unusually dark urine; loss of appetite that lasts several days or longer; severe nausea; or stomach pain. These may be early signs of liver problems.

Use caution when driving, operating machinery, or performing other hazardous activities. Serzone may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

Avoid alcohol during treatment with Serzone. Alcohol may increase drowsiness and dizziness while taking Serzone.

What you should find out before taking Serzone

Do not take Serzone if you are taking any of the following drugs:
- a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate);
- terfenadine (Seldane, Seldane-D);
- astemizole (Hismanal);
- cisapride (Propulsid);
- pimozide (Orap);
- triazolam (Halcion); or
- carbamazepine (Tegretol, Tegretol XR, Epitol, Carbatrol).

These drugs can cause very serious interactions with Serzone that could lead to seizures, heart damage, and even death.

Before taking this medication, tell your doctor if you have:
- heart disease, high or low blood pressure, or irregular heartbeats;
- seizures;
- had manic episodes (extreme agitation or excitability);
- kidney disease; or
- liver disease.

You may not be able to take Serzone, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Serzone is in the FDA pregnancy category C. This means that it is not known whether Serzone will harm an unborn baby. Do not take Serzone without first talking to your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether Serzone passes into breast milk. Do not take Serzone without first talking to your doctor if you are breast-feeding.

If you are over 60 years of age, you may be more likely to experience side effects from Serzone.

How should take Serzone

Take Serzone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain the instructions to you.

Take each dose with a full glass of water.

Do not stop taking Serzone without first talking to your doctor. It may be several weeks before you begin to feel better, and you may require continuous treatment for quite some time.

Store Serzone at room temperature away from moisture and heat.

If you miss a dose:

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take only the next one as directed. Do not take a double dose of this medication.

What happens if you overdose:

Seek emergency medical attention.

Symptoms of a Serzone overdose include drowsiness, nausea, vomiting, and seizures.

Avoid while taking Serzone

Use caution when driving, operating machinery, or performing other hazardous activities. Serzone may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.

Avoid alcohol during treatment with Serzone. Alcohol may increase drowsiness and dizziness while taking Serzone.

Possible side effects of Serzone

In rare cases, treatment with Serzone has been associated with serious liver problems, sometimes resulting in liver transplant or death. Contact your doctor immediately if you experience yellowing of the skin or eyes; unusually dark urine; loss of appetite that lasts several days or longer; severe nausea; or stomach pain. These may be early signs of liver problems.

If you experience any of the following uncommon but serious side effects, stop taking Serzone and seek emergency medical attention or contact your doctor immediately:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
- fainting; or
- prolonged, painful, or inappropriate erections (this could lead to a serious condition requiring surgery).

Other, less serious side effects may be more likely to occur. Continue to take Serzone and talk to your doctor when it is convenient if you experience:
- dizziness, lightheadedness, or drowsiness;
- upset stomach;
- insomnia;
- dry mouth;
- constipation; or
- blurred or abnormal vision.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Serzone

Do not take Serzone if you are taking any of the following drugs:
- a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate);
- terfenadine (Seldane, Seldane-D);
- astemizole (Hismanal);
- cisapride (Propulsid);
- carbamazepine (Tegretol, Tegretol XR, Epitol, Carbatrol);
- triazolam (Halcion); or
- pimozide (Orap).

These drugs can have very serious interactions with Serzone that could lead to seizures, heart damage, and even death.

Many other drugs may interact with Serzone. Talk to your doctor before taking any other medications during treatment with Serzone, especially any of the following:
- haloperidol (Haldol);
- alprazolam (Xanax);
- lorazepam (Ativan);
- cyclosporine (Neoral, Sandimmune);
- tacrolimus (Prograf);
- digoxin (Lanoxin, Lanoxicaps);
- phenytoin (Dilantin);
- warfarin (Coumadin); or
- atorvastatin (Lipitor), lovastatin (Mevacor), or simvastatin (Zocor).

You may require a dosage adjustment or special monitoring during treatment if you are taking any of these medicines.

Drugs other than those listed here may also interact with Serzone. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

All prescription drugs:

A
abilify accupril accutane acetaminophen aciphex actifed actonel actos acyclovir adalat adderall adipex advair advil albuterol alesse aleve allegra allopurinol amaryl ambien amiodarone amitriptyline amoxicillin amoxil amphetamine anacin aprazolam aricept asacol aspirin atenolol ativan atorvastatin atrovent augmentin avandia avapro avastin avelox azmacort
B
baclofen
bactrim bactroban baycol benadryl bextra biaxin boniva bontril buspar buspirone
C
caduet campral camptosar capoten captopril cardizem cardura carisoprodol casodex catapress cefzil celebrex celexa cellcept cephalexin cialis cipro ciprodex clarinex claritin climara clindamycin clonazepam clonidine codeine codeprex combivent combivir concerta copaxone coreg coricidin cotrim coumadin cozaar crestor cubicin cyclobenzaprine cymbalta
D
darvocet demerol depakote desogen detrol dextromethorphan diazepam diclofenac didrex diflucan digoxin dilantin diltiazem dimetapp diovan diprivan ditropan doxazosin doxycycline drixoral duragesic dyazide
E
effexor elavil elocon eloxatin emend enalapril enbrel endocet engerix-b entex epogen epzicom erbitux ertaczo ery-tab erythromycin estradiol evista 
F
fabrazyme famotidine fazaclo fenofibrate fioricet fiorinal flexeril flomax flonase flovent fluoxetine fosamax fosrenol furosemide  
G
gabapentin gamimune gemfibrozil gemzar glipizide glucophage glucotrol glucovance glyburide glyburide guaifenesin guaifenex 
H
herceptin humalog humira hydroxyzine hyzaar  
I
ibuprofen imdur imitrex imodium inderal insulin integrilin iressa 
K
kaletra keflex kenalog keppra ketek klonopin kytril  
L
lamictal lamisil lanoxin lantus lasix lescol levaquin levitra levothyroxine levoxyl lexapro lidoderm lipitor lisinopril lithium lorazepam lortab lotensin lotrel lotrisone lovenox lupron luveris  
M
macrobid magnevist meclizine medroxyprogesterone meridia metformin methadone methamphetamine methotrexate methylphenidate methylprednisolone metoclopramide metoprolol metronidazole miacalcin minocycline mobic monopril morphine motrin myfortic  
N
naproxen nasacort nasonex natrecor neulasta neupogen neurontin nexium nifedipine nitrofurantoin norco nortriptyline norvasc  
O
omeprazole omnicef orthovisc oxybutynin oxycodone oxycontin oxytrol  
P
paraplatin patanol paxil pegasys penicillin pepcid percocet percodan percogesic phendimetrazine phenergan phentermine phenytoin plavix plendil potassium pravachol prednisone premarin prempro prevacid prilosec prinivil procrit promethazine propecia propofol propoxyphene propranolol protonix proventil provigil prozac pseudoephedrine pulmicort  
R
ranitidine rebetol reglan relafen relpax remeron remicade renagel renova rhinocort riomet risperdal risperidone ritalin rituxan rocephin rogaine roxicet  
S
sanctura seasonale sensipar serevent seroquel serzone singulair skelaxin soma somavert sonata spiriva spironolactone strattera striant sustiva synagis synthroid 
T
tamoxifen tavist taxol taxotere tegretol temazepam tenormin tenuate tequin terazosin tetracycline tiazac tindamax titralac tobradex topamax toprol tramadol trazodone triamcinolone triaminic triamterene tricor trileptal trimox triphasil trizivir truvada tylenol 
U
ultane ultracet ultram uroxatral
V
valium valtrex vaniqa vasotec velcade verapamil viagra vicodin vicoprofen vidaza viracept viread vytorin  
W
warfarin wellbutrin  
X
xalatan xanax xenical xifaxan xolair xopenex xyrem  
Y
yasmin 
Z
zanaflex zantac zavesca zelnorm zemplar zerit zestoretic zestril zetia ziac zithromax zocor zofran zoladex zoloft zometa zorbtive zosyn zovirax zyrtec zyvox