What is spironolactone
is in a class of drugs called potassium-sparing diuretics
(water pill). It is used to reduce the amount of fluid in
your body without causing the loss of potassium.
is used to treat edema (swelling) and hypertension (high blood
is also used to treat potassium deficiency and hyperaldosteronism
(a hormonal disorder).
may also be used for purposes other than those listed in this
General medical information about spironolactone
To reduce nighttime urination, take spironolactone
early in the day unless otherwise directed by your doctor.
Take spironolactone with food or milk to lessen stomach
Do not use salt substitutes or low-sodium
milk products that contain potassium while taking spironolactone.
These products could cause high levels of potassium in your
blood. Ask your doctor or pharmacist about any salt substitutes
you are taking.
Who should not take spironolactone
Before taking spironolactone, tell your doctor if
- have kidney disease;
- have liver disease;
- have diabetes mellitus;
- have high levels
of potassium in your blood; or
- are taking a potassium
supplement or an angiotensin-converting-enzyme inhibitor
(ACE inhibitor) such as captopril (Capoten), benazepril
(Lotensin), lisinopril (Prinivil, Zestril), enalapril (Vasotec),
You may not be able to take spironolactone,
or you may require a dosage adjustment or special monitoring
during treatment if you have any of the conditions listed
Spironolactone is in the FDA pregnancy category
D. This means that spironolactone is known to harm an unborn
baby. Do not take spironolactone if you are pregnant.
It is not known whether spironolactone passes into breast
milk. Do not take spironolactone without first talking to
your doctor if you are breast-feeding a baby.
How should take spironolactone Take spironolactone exactly as directed by your doctor.
If you do not understand these directions, ask your pharmacist,
nurse, or doctor to explain them to you.
dose with a full glass of water.
with food or milk to lessen stomach upset.
nighttime urination, take spironolactone early in the day
unless otherwise directed by your doctor.
stop taking spironolactone suddenly even if you feel better.
Stopping suddenly could make your condition worse.
Store spironolactone at room temperature away from moisture
If you miss a dose: Take the missed dose as soon as you remember. If
it is almost time for your next dose, skip the dose you
missed and take only your next regularly scheduled dose
as directed. Do not take a double dose of this medication.
What happens if you overdose: Seek emergency medical attention.
of a spironolactone overdose include an irregular heartbeat,
lethargy, fatigue, weakness, drowsiness, dizziness, confusion,
shortness of breath, nausea, and vomiting.
Avoid while taking spironolactone Do not use salt substitutes or low-sodium milk products
that contain potassium while taking spironolactone. These
products could cause high levels of potassium in your blood.
Ask your doctor or pharmacist about any salt substitutes
you are taking.
Possible side effects of spironolactone Stop taking spironolactone and seek emergency medical
attention if you experience any of the following serious
- an allergic reaction (difficulty
breathing; closing of your throat; swelling of your lips,
tongue, or face; or hives);
- an irregular heartbeat,
shortness of breath, fatigue, confusion, weakness, numbness,
or tingling (caused by high levels of potassium in your
- decreased urination.
serious side effects may be more likely to occur. Continue
to take spironolactone and talk to your doctor if you experience
- unusual headache or dizziness;
diarrhea, or a decrease in appetite;
- dry mouth;
- muscle cramps; or
of the voice, excessive hair growth, or enlarged breasts.
Side effects other than those listed here may also
occur. Talk to your doctor about any side effect that seems
unusual or that is especially bothersome.
What other drugs will affect spironolactone Before taking spironolactone tell your doctor if
you are taking any of the following medications:
lithium (Lithobid, Eskalith, others);
- a nonsteroidal anti-inflammatory drug
(NSAID) such as ibuprofen (Motrin, Advil, Nuprin), naproxen
(Naprosyn, Anaprox, Aleve), ketoprofen (Orudis, Orudis KT,
Oruvail), indomethacin (Indocin), diclofenac (Cataflam,
Voltaren), etodolac (Lodine), nabumetone (Relafen), oxaprozin
(Daypro), piroxicam (Feldene), sulindac (Clinoril), tolmetin
(Tolectin), fenoprofen (Nalfon), ketorolac (Toradol), or
flurbiprofen (Ansaid); or
- a diabetes medication
such as glipizide (Glucotrol), glyburide (Micronase, Glynase,
Diabeta), chlorpropamide (Diabinese), tolazamide (Tolinase),
tolbutamide (Orinase), and others.
You may not be
able to take spironolactone, or you may require a dosage
adjustment or special monitoring during treatment if you
are taking any of the medications listed above.
before taking spironolactone, tell your doctor if you are
taking any other medicine to treat high blood pressure,
water retention, heart problems, prostate problems, or another
condition. Some medicines used to treat these conditions
may interact with spironolactone and the effects on your
heart may be increased.
other than those listed here may also interact with spironolactone.
Talk to your doctor and pharmacist before taking any prescription
or over-the-counter medicines.