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Spironolactone

What is spironolactone

Spironolactone is in a class of drugs called potassium-sparing diuretics (water pill). It is used to reduce the amount of fluid in your body without causing the loss of potassium.

Spironolactone is used to treat edema (swelling) and hypertension (high blood pressure).

Spironolactone is also used to treat potassium deficiency and hyperaldosteronism (a hormonal disorder).

Spironolactone may also be used for purposes other than those listed in this medication guide.

General medical information about spironolactone

To reduce nighttime urination, take spironolactone early in the day unless otherwise directed by your doctor.

Take spironolactone with food or milk to lessen stomach upset.

Do not use salt substitutes or low-sodium milk products that contain potassium while taking spironolactone. These products could cause high levels of potassium in your blood. Ask your doctor or pharmacist about any salt substitutes you are taking.

Who should not take spironolactone

Before taking spironolactone, tell your doctor if you
- have kidney disease;
- have liver disease;
- have diabetes mellitus;
- have high levels of potassium in your blood; or
- are taking a potassium supplement or an angiotensin-converting-enzyme inhibitor (ACE inhibitor) such as captopril (Capoten), benazepril (Lotensin), lisinopril (Prinivil, Zestril), enalapril (Vasotec), or others.

You may not be able to take spironolactone, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Spironolactone is in the FDA pregnancy category D. This means that spironolactone is known to harm an unborn baby. Do not take spironolactone if you are pregnant.

It is not known whether spironolactone passes into breast milk. Do not take spironolactone without first talking to your doctor if you are breast-feeding a baby.

How should take spironolactone

Take spironolactone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Take spironolactone with food or milk to lessen stomach upset.

To reduce nighttime urination, take spironolactone early in the day unless otherwise directed by your doctor.

Do not stop taking spironolactone suddenly even if you feel better. Stopping suddenly could make your condition worse.

Store spironolactone at room temperature away from moisture and heat.

If you miss a dose:

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose as directed. Do not take a double dose of this medication.

What happens if you overdose:

Seek emergency medical attention.

Symptoms of a spironolactone overdose include an irregular heartbeat, lethargy, fatigue, weakness, drowsiness, dizziness, confusion, shortness of breath, nausea, and vomiting.

Avoid while taking spironolactone

Do not use salt substitutes or low-sodium milk products that contain potassium while taking spironolactone. These products could cause high levels of potassium in your blood. Ask your doctor or pharmacist about any salt substitutes you are taking.

Possible side effects of spironolactone

Stop taking spironolactone and seek emergency medical attention if you experience any of the following serious side effects:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
- an irregular heartbeat, shortness of breath, fatigue, confusion, weakness, numbness, or tingling (caused by high levels of potassium in your blood); or
- decreased urination.

Other, less serious side effects may be more likely to occur. Continue to take spironolactone and talk to your doctor if you experience
- unusual headache or dizziness;
- nausea, diarrhea, or a decrease in appetite;
- dry mouth;
- bloating;
- muscle cramps; or
- lowering of the voice, excessive hair growth, or enlarged breasts.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect spironolactone

Before taking spironolactone tell your doctor if you are taking any of the following medications:
- lithium (Lithobid, Eskalith, others);
- probenecid (Benemid);
- a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin), naproxen (Naprosyn, Anaprox, Aleve), ketoprofen (Orudis, Orudis KT, Oruvail), indomethacin (Indocin), diclofenac (Cataflam, Voltaren), etodolac (Lodine), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), tolmetin (Tolectin), fenoprofen (Nalfon), ketorolac (Toradol), or flurbiprofen (Ansaid); or
- a diabetes medication such as glipizide (Glucotrol), glyburide (Micronase, Glynase, Diabeta), chlorpropamide (Diabinese), tolazamide (Tolinase), tolbutamide (Orinase), and others.

You may not be able to take spironolactone, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medications listed above.

Also, before taking spironolactone, tell your doctor if you are taking any other medicine to treat high blood pressure, water retention, heart problems, prostate problems, or another condition. Some medicines used to treat these conditions may interact with spironolactone and the effects on your heart may be increased.

Drugs other than those listed here may also interact with spironolactone. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

All prescription drugs:

A
abilify accupril accutane acetaminophen aciphex actifed actonel actos acyclovir adalat adderall adipex advair advil albuterol alesse aleve allegra allopurinol amaryl ambien amiodarone amitriptyline amoxicillin amoxil amphetamine anacin aprazolam aricept asacol aspirin atenolol ativan atorvastatin atrovent augmentin avandia avapro avastin avelox azmacort
B
baclofen
bactrim bactroban baycol benadryl bextra biaxin boniva bontril buspar buspirone
C
caduet campral camptosar capoten captopril cardizem cardura carisoprodol casodex catapress cefzil celebrex celexa cellcept cephalexin cialis cipro ciprodex clarinex claritin climara clindamycin clonazepam clonidine codeine codeprex combivent combivir concerta copaxone coreg coricidin cotrim coumadin cozaar crestor cubicin cyclobenzaprine cymbalta
D
darvocet demerol depakote desogen detrol dextromethorphan diazepam diclofenac didrex diflucan digoxin dilantin diltiazem dimetapp diovan diprivan ditropan doxazosin doxycycline drixoral duragesic dyazide
E
effexor elavil elocon eloxatin emend enalapril enbrel endocet engerix-b entex epogen epzicom erbitux ertaczo ery-tab erythromycin estradiol evista 
F
fabrazyme famotidine fazaclo fenofibrate fioricet fiorinal flexeril flomax flonase flovent fluoxetine fosamax fosrenol furosemide  
G
gabapentin gamimune gemfibrozil gemzar glipizide glucophage glucotrol glucovance glyburide glyburide guaifenesin guaifenex 
H
herceptin humalog humira hydroxyzine hyzaar  
I
ibuprofen imdur imitrex imodium inderal insulin integrilin iressa 
K
kaletra keflex kenalog keppra ketek klonopin kytril  
L
lamictal lamisil lanoxin lantus lasix lescol levaquin levitra levothyroxine levoxyl lexapro lidoderm lipitor lisinopril lithium lorazepam lortab lotensin lotrel lotrisone lovenox lupron luveris  
M
macrobid magnevist meclizine medroxyprogesterone meridia metformin methadone methamphetamine methotrexate methylphenidate methylprednisolone metoclopramide metoprolol metronidazole miacalcin minocycline mobic monopril morphine motrin myfortic  
N
naproxen nasacort nasonex natrecor neulasta neupogen neurontin nexium nifedipine nitrofurantoin norco nortriptyline norvasc  
O
omeprazole omnicef orthovisc oxybutynin oxycodone oxycontin oxytrol  
P
paraplatin patanol paxil pegasys penicillin pepcid percocet percodan percogesic phendimetrazine phenergan phentermine phenytoin plavix plendil potassium pravachol prednisone premarin prempro prevacid prilosec prinivil procrit promethazine propecia propofol propoxyphene propranolol protonix proventil provigil prozac pseudoephedrine pulmicort  
R
ranitidine rebetol reglan relafen relpax remeron remicade renagel renova rhinocort riomet risperdal risperidone ritalin rituxan rocephin rogaine roxicet  
S
sanctura seasonale sensipar serevent seroquel serzone singulair skelaxin soma somavert sonata spiriva spironolactone strattera striant sustiva synagis synthroid 
T
tamoxifen tavist taxol taxotere tegretol temazepam tenormin tenuate tequin terazosin tetracycline tiazac tindamax titralac tobradex topamax toprol tramadol trazodone triamcinolone triaminic triamterene tricor trileptal trimox triphasil trizivir truvada tylenol 
U
ultane ultracet ultram uroxatral
V
valium valtrex vaniqa vasotec velcade verapamil viagra vicodin vicoprofen vidaza viracept viread vytorin  
W
warfarin wellbutrin  
X
xalatan xanax xenical xifaxan xolair xopenex xyrem  
Y
yasmin 
Z
zanaflex zantac zavesca zelnorm zemplar zerit zestoretic zestril zetia ziac zithromax zocor zofran zoladex zoloft zometa zorbtive zosyn zovirax zyrtec zyvox