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What is Striant

Testosterone is a naturally occurring "male" sex hormone necessary for many processes in the body.

Striant is used to treat men with low testosterone levels.

Striant may also be used for purposes other than those listed in this medication guide.

General medical information about Striant

Notify your doctor if you experience nausea; vomiting; swelling of the ankles; changes in skin color; too frequent or prolonged erections; breathing disturbances, including those associated with sleep; or yellowing of the skin or eyes.

Notify your doctor if a female partner experiences male-pattern baldness, excessive body hair growth, an increase in acne, menstrual irregularities, or signs of masculinity.

What you should discuss with your doctor before using Striant

Do not use Striant if you have cancer of the breast or prostate. Testosterone may worsen some cancers of these types.

Before using Striant, tell your doctor if you have:
- diabetes;
- sleep apnea or if you have risk factors for sleep apnea (e.g., obesity, chronic lung disease);
- heart disease; or
- liver disease or kidney disease.

You may not be able to use Striant, or you may need a dosage adjustment or special monitoring if you have any of the conditions listed above.

Striant is not approved for use by women and must not be used by women. Striant is in the FDA pregnancy category X. This means that testosterone is known to cause birth defects in an unborn baby. Do not use Striant if you are pregnant or could become pregnant during treatment.

Striant is not approved for use by women and must not be used by women. It is not known whether testosterone from the buccal system will pass into breast milk.Do not use Striant if you are breast-feeding a baby.

Men over 65 years of age that use Striant may be at increased risk for the development of prostatic enlargement or cancer. You may not be able to use buccal system testosterone, or you may require a lower dose or special monitoring.

How should you use Striant

Use Striant exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

To use the Striant (Striant):
- Hold one system with the flat side on your fingertip. Place the curved side onto your gum, as high as possible above the left or right incisor tooth. Hold your finger on the outside of your lip over the system for 30 seconds to ensure the system is attached to the gum. If the system sticks to the cheek and not the gum, this is acceptable.
- The system should remain in place for 12 hours. To remove the system, move it slightly toward the back or front of the mouth then slide it down toward the teeth from removal. With each new application, rotate sides of the mouth. Check to see that the system is in place after eating, drinking, brushing the teeth, or using mouthwash.
- If a system falls off before 8 hours of use, remove it and replace it with a new system in the same place. Change the system and rotate sides of the mouth 12 hours after application of the original system. If a system falls off after 8 hours but before 12 hours of use, remove the system and replace it with a new system above the opposite incisor. This will serve as the second dose for the day.

Your doctor may want to perform tests to monitor the amount of testosterone in the body, liver function, prostate function, or other factors during treatment with Striant.

It is important to use Striant regularly to get the most benefit.

Dispose of all used systems properly, out of the reach of children and pets.

Store Striant at room temperature away from moisture and heat.

If you miss a dose:

Apply the next system as soon as you remember. Do not use two doses simultaneously, unless otherwise directed by your doctor.

What happens if you overdose:

An overdose of Striant is not likely to threaten life. If you do suspect an overdose, or if a system has been ingested, call an emergency room or poison control center for advice.

What should you avoid while using Striant

Regularly inspect the gum

Where the Striant is applied. Promptly report any changes to your doctor or dentist.

Possible side effects of Striant

If you experience any of the following serious side effects, stop using Striant and seek emergency medical attention or contact your doctor immediately:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- nausea or vomiting;
- changes in skin color;
- swelling of the ankles;
- breathing disturbances, including those associated with sleep;
- too frequent or prolonged erections; or
- liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, or severe fatigue).

Other, less serious side effects may be more likely to occur. Continue to use Striant and talk to your doctor if you experience
- irritation or changes in the gum at the system application site;
- emotional changes;
- increased blood pressure;
- decreased interest in sex;
- changes in blood cholesterol or number of red blood cells (detected by blood tests);
- prostate changes or difficulty urinating;
- enlarged, swollen or tender breasts; or
- acne.

Notify your doctor if a female partner experiences male-pattern baldness, excessive body hair growth, an increase in acne, menstrual irregularities, or signs of masculinity.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Striant

Before using Striant, tell your doctor if you are taking any of the following medicines:
- warfarin (Coumadin);
- insulin or an oral diabetes medication such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), repaglinide (Prandin), rosiglitazone (Avandia), pioglitazone (Actos), and others;
- propranolol (Inderal, Inderal LA, others); or
- a corticosteroid such as hydrocortisone (Cortef, Hydrocortone, Solu-Cortef), dexamethasone (Decadron, Hexadrol others), methylprednisolone (Depo-Medrol, Medrol, Solu-Medrol), prednisolone (Prelone Pediapred), prednisone (Deltasone, Orasone, others), and others.

You may not be able to use Striant, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with Striant. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

All prescription drugs:

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