What is Zestoretic
is a thiazide diuretic (water pill). It increases the amount
of salt and water you lose in your urine. Hydrochlorothiazide
is used to lower blood pressure and to decrease edema (swelling).
is in a class of drugs called angiotensin-converting-enzyme
inhibitors (ACE inhibitors). Lisinopril is used to lower blood
pressure and to relieve the symptoms of congestive heart failure,
including shortness of breath and swelling of the legs.
is used to treat hypertension (high blood pressure).
may also be used for purposes other than those listed in this
General medical information about Zestoretic
Lisinopril is in the FDA pregnancy category D. This
means that lisinopril is known to harm an unborn baby. When
used during the second and third trimesters of pregnancy,
lisinopril can cause injury and even death to the developing
fetus. Do not take Zestoretic if you are pregnant.
Lisinopril may increase the risk of dangerous allergic reactions.
Before taking Zestoretic, tell your doctor if you have ever
had an allergic reaction that involved swelling of your
lips, face, tongue, or throat or difficulty breathing. Seek
emergency medical attention if you develop any of these
symptoms while taking Zestoretic.
Use caution when
driving, operating machinery, or performing other hazardous
activities. Zestoretic may cause dizziness or drowsiness.
If you experience dizziness or drowsiness, avoid these activities.
Also use caution when rising from a sitting or lying position.
Who should not take Zestoretic
Do not take Zestoretic if you have an allergy to
sulfa-based drugs such as sulfa antibiotics. You may have
an allergic reaction to hydrochlorothiazide.
is in the FDA pregnancy category D. This means that lisinopril
is known to harm an unborn baby. When used during the second
and third trimesters of pregnancy, lisinopril can cause
injury and even death to the developing fetus. Do not take
Zestoretic if you are pregnant.
Before taking Zestoretic,
tell your doctor if you
- have diabetes,
- have a collagen vascular disease such
as systemic lupus erythematosus or scleroderma,
- have kidney disease,
have liver disease,
- have a blood or bone marrow
- have any type of heart disease or have
had a stroke,
- are taking salt substitutes, potassium
supplements (e.g., K-Dur, Klor-Con), or potassium-sparing
diuretics such as amiloride (Midamor), triamterene (Dyrenium,
Dyazide, Maxzide), or spironolactone (Aldactone); or
are on a salt-restricted diet or have high levels of potassium
in your blood.
You may not be able to take Zestoretic,
or you may require a dosage adjustment or special monitoring
during treatment if you have any of the conditions listed
Lisinopril is in the FDA pregnancy category
D. This means that lisinopril is known to harm an unborn
baby. When used during the second and third trimesters of
pregnancy, lisinopril can cause injury and even death to
the developing fetus. Do not take Zestoretic if you are
Hydrochlorothiazide passes into breast
milk and may harm a nursing infant. It is not known whether
lisinopril passes into breast milk. Do not take this medication
without first talking to your doctor if you are breast-feeding
If you are over 60 years of age, you may
be more likely to experience side effects from Zestoretic.
Your doctor may prescribe a lower dose of this medication.
How should take Zestoretic Take Zestoretic exactly as directed by your doctor.
If you do not understand these directions, ask your pharmacist,
nurse, or doctor to explain them to you.
dose with a full glass of water.
Do not stop taking
this medication without first talking to your doctor. If
you stop taking your medication, your condition could become
Store Zestoretic at room temperature away
from moisture and heat.
If you miss a dose: Take the missed dose as soon as you remember. However,
if it is almost time for your next dose, skip the missed
dose and take only your next regularly scheduled dose. Do
not take a double dose of this medication.
What happens if you overdose: Seek emergency medical attention.
of a Zestoretic overdose include increased urination, nausea,
vomiting, diarrhea, dizziness, fainting, weakness, fatigue,
Avoid while taking Zestoretic Use caution when driving, operating machinery, or
performing other hazardous activities. Zestoretic may cause
dizziness or drowsiness. If you experience dizziness or
drowsiness, avoid these activities. Also use caution when
rising from a sitting or lying position.
cautiously. Alcohol may further lower blood pressure, causing
increased drowsiness and dizziness while you are taking
Avoid a diet high in salt. Too much salt
may cause your body to retain water and may decrease the
effects of hydrochlorothiazide. Ask your doctor or nurse
about low-salt diet alternatives.
Do not use salt
substitutes or potassium supplements without first talking
to your doctor while taking Zestoretic. These products could
cause potassium levels in your blood to become dangerously
Avoid prolonged exposure to sunlight. Hydrochlorothiazide
may increase the sensitivity of your skin to sunlight. Use
a sunscreen and wear protective clothing when exposure to
the sun is unavoidable.
Heavy sweating, vomiting,
diarrhea, or other causes of fluid loss may lead to very
low blood pressure, dizziness, and fainting during therapy
with Zestoretic. Maintain proper fluid intake to prevent
dehydration and related adverse effects.
Possible side effects of Zestoretic If you experience any of the following serious side
effects, stop taking Zestoretic and seek emergency medical
- an allergic reaction (difficulty breathing;
closing of your throat; swelling of your lips, tongue, or
face; or hives);
- fainting spells;
fatigue or abnormal bleeding or bruising;
skin or eyes;
- fever, chills,
or a sore throat;
- little or no urine;
irregular heartbeats; or
- increased swelling.
Other, less serious side effects may be more likely to occur.
Continue to take Zestoretic and talk to your doctor if you
- dizziness or lightheadedness;
- tingling or numbness
in your arms, legs, hands, or feet;
- excessive urination;
- muscle weakness or cramps;
- increased hunger
- nausea, vomiting, diarrhea, constipation,
decreased appetite, or changes in taste;
- dry, tickling cough;
or depression; or
- itching, rash, or increased sweating.
Side effects other than those listed here may also
occur. Talk to your doctor about any side effect that seems
unusual or that is especially bothersome.
What other drugs will affect Zestoretic Before taking Zestoretic, tell your doctor if you
are taking any of the medicines listed below:
potassium supplement such as K-Dur, Klor-Con, and others;
- a salt substitute that contains potassium;
another diuretic (water pill) especially triamterene (Dyrenium,
Maxzide, Dyazide), spironolactone (Aldactone), or amiloride
- cholestyramine (Questran) or colestipol
- a nonsteroidal anti-inflammatory drug
(NSAID) such as ibuprofen (Motrin, Advil), ketoprofen (Orudis,
Orudis KT, Oruvail), naproxen (Naprosyn, Anaprox, Aleve),
diclofenac (Cataflam, Voltaren), etodolac (Lodine), fenoprofen
(Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin),
ketorolac (Toradol), mefenamic acid (Ponstel), nabumetone
(Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac
(Clinoril), or tolmetin (Tolectin);
- an oral diabetes
medication such as glipizide (Glucotrol), glyburide (Micronase,
Glynase, Diabeta), chlorpropamide (Diabinese), tolazamide
(Tolinase), tolbutamide (Orinase), and others;
tetracycline (Sumycin, others);
- lithium (Lithane,
Lithobid, Eskalith, others);
- a calcium channel
blocker such as amlodipine (Norvasc), diltiazem (Cardizem,
Dilacor XR, Tiazac), nifedipine (Adalat, Procardia), verapamil
(Calan, Verelan, Isoptin), and others;
(Cardura), prazosin (Minipress), or terazosin (Hytrin);
- reserpine, guanadrel (Hylorel), or guanethidine
- a nitrate such as nitroglycerin (Nitrostat,
Transderm-Nitro, Nitro-Dur, Nitro-Bid, Minitran, others),
isosorbide mononitrate (Imdur, ISMO), or isosorbide dinitrate
- a pain reliever such as
codeine, morphine (MS Contin, MSIR, Roxanol, others), propoxyphene
(Darvocet, Darvon, Wygesic), oxycodone (Percocet, Percodan),
meperidine (Demerol), and others;
- a barbiturate
such as phenobarbital (Luminal, Solfoton), amobarbital (Amytal),
secobarbital (Seconal), and butabarbital (Butisol); or
a steroid medicine such as cortisone (Cortone), dexamethasone
(Decadron, Hexadrol), betamethasone (Celestone), hydrocortisone
(Cortef, Hydrocortone), prednisone (Orasone, Deltasone),
prednisolone (Delta Cortef, Prelone), methylprednisolone
(Medrol), and others.
You may not be able to take
Zestoretic, or you may require a dosage adjustment or special
monitoring during your treatment if you are taking any of
the medicines listed above.
other than those listed here may also interact with Zestoretic
or affect your condition. Talk to your doctor and pharmacist
before taking any prescription or over-the-counter medicines.