prescription drugs
Free drug information service 
All available medical information about prescription drugs 

Zestoretic

What is Zestoretic

Hydrochlorothiazide is a thiazide diuretic (water pill). It increases the amount of salt and water you lose in your urine. Hydrochlorothiazide is used to lower blood pressure and to decrease edema (swelling).

Lisinopril is in a class of drugs called angiotensin-converting-enzyme inhibitors (ACE inhibitors). Lisinopril is used to lower blood pressure and to relieve the symptoms of congestive heart failure, including shortness of breath and swelling of the legs.

Zestoretic is used to treat hypertension (high blood pressure).

Zestoretic may also be used for purposes other than those listed in this medication guide.

General medical information about Zestoretic

Lisinopril is in the FDA pregnancy category D. This means that lisinopril is known to harm an unborn baby. When used during the second and third trimesters of pregnancy, lisinopril can cause injury and even death to the developing fetus. Do not take Zestoretic if you are pregnant.

Lisinopril may increase the risk of dangerous allergic reactions. Before taking Zestoretic, tell your doctor if you have ever had an allergic reaction that involved swelling of your lips, face, tongue, or throat or difficulty breathing. Seek emergency medical attention if you develop any of these symptoms while taking Zestoretic.

Use caution when driving, operating machinery, or performing other hazardous activities. Zestoretic may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Also use caution when rising from a sitting or lying position.

Who should not take Zestoretic

Do not take Zestoretic if you have an allergy to sulfa-based drugs such as sulfa antibiotics. You may have an allergic reaction to hydrochlorothiazide.

Lisinopril is in the FDA pregnancy category D. This means that lisinopril is known to harm an unborn baby. When used during the second and third trimesters of pregnancy, lisinopril can cause injury and even death to the developing fetus. Do not take Zestoretic if you are pregnant.

Before taking Zestoretic, tell your doctor if you
- have diabetes,
- have gout,
- have a collagen vascular disease such as systemic lupus erythematosus or scleroderma,
- have pancreatitis,
- have kidney disease,
- have liver disease,
- have a blood or bone marrow disease,
- have any type of heart disease or have had a stroke,
- are taking salt substitutes, potassium supplements (e.g., K-Dur, Klor-Con), or potassium-sparing diuretics such as amiloride (Midamor), triamterene (Dyrenium, Dyazide, Maxzide), or spironolactone (Aldactone); or
- are on a salt-restricted diet or have high levels of potassium in your blood.

You may not be able to take Zestoretic, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Lisinopril is in the FDA pregnancy category D. This means that lisinopril is known to harm an unborn baby. When used during the second and third trimesters of pregnancy, lisinopril can cause injury and even death to the developing fetus. Do not take Zestoretic if you are pregnant.

Hydrochlorothiazide passes into breast milk and may harm a nursing infant. It is not known whether lisinopril passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

If you are over 60 years of age, you may be more likely to experience side effects from Zestoretic. Your doctor may prescribe a lower dose of this medication.

How should take Zestoretic

Take Zestoretic exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Do not stop taking this medication without first talking to your doctor. If you stop taking your medication, your condition could become worse.

Store Zestoretic at room temperature away from moisture and heat.

If you miss a dose:

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if you overdose:

Seek emergency medical attention.

Symptoms of a Zestoretic overdose include increased urination, nausea, vomiting, diarrhea, dizziness, fainting, weakness, fatigue, and unconsciousness.

Avoid while taking Zestoretic

Use caution when driving, operating machinery, or performing other hazardous activities. Zestoretic may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Also use caution when rising from a sitting or lying position.

Use alcohol cautiously. Alcohol may further lower blood pressure, causing increased drowsiness and dizziness while you are taking Zestoretic.

Avoid a diet high in salt. Too much salt may cause your body to retain water and may decrease the effects of hydrochlorothiazide. Ask your doctor or nurse about low-salt diet alternatives.

Do not use salt substitutes or potassium supplements without first talking to your doctor while taking Zestoretic. These products could cause potassium levels in your blood to become dangerously high.

Avoid prolonged exposure to sunlight. Hydrochlorothiazide may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

Heavy sweating, vomiting, diarrhea, or other causes of fluid loss may lead to very low blood pressure, dizziness, and fainting during therapy with Zestoretic. Maintain proper fluid intake to prevent dehydration and related adverse effects.

Possible side effects of Zestoretic

If you experience any of the following serious side effects, stop taking Zestoretic and seek emergency medical attention:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
- fainting spells;
- unusual fatigue or abnormal bleeding or bruising;
- yellow skin or eyes;
- confusion;
- fever, chills, or a sore throat;
- little or no urine;
- irregular heartbeats; or
- increased swelling.

Other, less serious side effects may be more likely to occur. Continue to take Zestoretic and talk to your doctor if you experience
- dizziness or lightheadedness;
- headache;
- fatigue;
- tingling or numbness in your arms, legs, hands, or feet;
- excessive urination;
- muscle weakness or cramps;
- increased hunger or thirst;
- nausea, vomiting, diarrhea, constipation, decreased appetite, or changes in taste;
- sensitivity to sunlight;
- dry, tickling cough;
- anxiety or depression; or
- itching, rash, or increased sweating.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Zestoretic

Before taking Zestoretic, tell your doctor if you are taking any of the medicines listed below:
- a potassium supplement such as K-Dur, Klor-Con, and others;
- a salt substitute that contains potassium;
- another diuretic (water pill) especially triamterene (Dyrenium, Maxzide, Dyazide), spironolactone (Aldactone), or amiloride (Midamor);
- cholestyramine (Questran) or colestipol (Colestid);
- a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil), ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Anaprox, Aleve), diclofenac (Cataflam, Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), mefenamic acid (Ponstel), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin);
- an oral diabetes medication such as glipizide (Glucotrol), glyburide (Micronase, Glynase, Diabeta), chlorpropamide (Diabinese), tolazamide (Tolinase), tolbutamide (Orinase), and others;
- tetracycline (Sumycin, others);
- lithium (Lithane, Lithobid, Eskalith, others);
- a calcium channel blocker such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor XR, Tiazac), nifedipine (Adalat, Procardia), verapamil (Calan, Verelan, Isoptin), and others;
- doxazosin (Cardura), prazosin (Minipress), or terazosin (Hytrin);
- reserpine, guanadrel (Hylorel), or guanethidine (Ismelin);
- a nitrate such as nitroglycerin (Nitrostat, Transderm-Nitro, Nitro-Dur, Nitro-Bid, Minitran, others), isosorbide mononitrate (Imdur, ISMO), or isosorbide dinitrate (Isordil, Sorbitrate);
- a pain reliever such as codeine, morphine (MS Contin, MSIR, Roxanol, others), propoxyphene (Darvocet, Darvon, Wygesic), oxycodone (Percocet, Percodan), meperidine (Demerol), and others;
- a barbiturate such as phenobarbital (Luminal, Solfoton), amobarbital (Amytal), secobarbital (Seconal), and butabarbital (Butisol); or
- a steroid medicine such as cortisone (Cortone), dexamethasone (Decadron, Hexadrol), betamethasone (Celestone), hydrocortisone (Cortef, Hydrocortone), prednisone (Orasone, Deltasone), prednisolone (Delta Cortef, Prelone), methylprednisolone (Medrol), and others.

You may not be able to take Zestoretic, or you may require a dosage adjustment or special monitoring during your treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with Zestoretic or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

All prescription drugs:

A
abilify accupril accutane acetaminophen aciphex actifed actonel actos acyclovir adalat adderall adipex advair advil albuterol alesse aleve allegra allopurinol amaryl ambien amiodarone amitriptyline amoxicillin amoxil amphetamine anacin aprazolam aricept asacol aspirin atenolol ativan atorvastatin atrovent augmentin avandia avapro avastin avelox azmacort
B
baclofen
bactrim bactroban baycol benadryl bextra biaxin boniva bontril buspar buspirone
C
caduet campral camptosar capoten captopril cardizem cardura carisoprodol casodex catapress cefzil celebrex celexa cellcept cephalexin cialis cipro ciprodex clarinex claritin climara clindamycin clonazepam clonidine codeine codeprex combivent combivir concerta copaxone coreg coricidin cotrim coumadin cozaar crestor cubicin cyclobenzaprine cymbalta
D
darvocet demerol depakote desogen detrol dextromethorphan diazepam diclofenac didrex diflucan digoxin dilantin diltiazem dimetapp diovan diprivan ditropan doxazosin doxycycline drixoral duragesic dyazide
E
effexor elavil elocon eloxatin emend enalapril enbrel endocet engerix-b entex epogen epzicom erbitux ertaczo ery-tab erythromycin estradiol evista 
F
fabrazyme famotidine fazaclo fenofibrate fioricet fiorinal flexeril flomax flonase flovent fluoxetine fosamax fosrenol furosemide  
G
gabapentin gamimune gemfibrozil gemzar glipizide glucophage glucotrol glucovance glyburide glyburide guaifenesin guaifenex 
H
herceptin humalog humira hydroxyzine hyzaar  
I
ibuprofen imdur imitrex imodium inderal insulin integrilin iressa 
K
kaletra keflex kenalog keppra ketek klonopin kytril  
L
lamictal lamisil lanoxin lantus lasix lescol levaquin levitra levothyroxine levoxyl lexapro lidoderm lipitor lisinopril lithium lorazepam lortab lotensin lotrel lotrisone lovenox lupron luveris  
M
macrobid magnevist meclizine medroxyprogesterone meridia metformin methadone methamphetamine methotrexate methylphenidate methylprednisolone metoclopramide metoprolol metronidazole miacalcin minocycline mobic monopril morphine motrin myfortic  
N
naproxen nasacort nasonex natrecor neulasta neupogen neurontin nexium nifedipine nitrofurantoin norco nortriptyline norvasc  
O
omeprazole omnicef orthovisc oxybutynin oxycodone oxycontin oxytrol  
P
paraplatin patanol paxil pegasys penicillin pepcid percocet percodan percogesic phendimetrazine phenergan phentermine phenytoin plavix plendil potassium pravachol prednisone premarin prempro prevacid prilosec prinivil procrit promethazine propecia propofol propoxyphene propranolol protonix proventil provigil prozac pseudoephedrine pulmicort  
R
ranitidine rebetol reglan relafen relpax remeron remicade renagel renova rhinocort riomet risperdal risperidone ritalin rituxan rocephin rogaine roxicet  
S
sanctura seasonale sensipar serevent seroquel serzone singulair skelaxin soma somavert sonata spiriva spironolactone strattera striant sustiva synagis synthroid 
T
tamoxifen tavist taxol taxotere tegretol temazepam tenormin tenuate tequin terazosin tetracycline tiazac tindamax titralac tobradex topamax toprol tramadol trazodone triamcinolone triaminic triamterene tricor trileptal trimox triphasil trizivir truvada tylenol 
U
ultane ultracet ultram uroxatral
V
valium valtrex vaniqa vasotec velcade verapamil viagra vicodin vicoprofen vidaza viracept viread vytorin  
W
warfarin wellbutrin  
X
xalatan xanax xenical xifaxan xolair xopenex xyrem  
Y
yasmin 
Z
zanaflex zantac zavesca zelnorm zemplar zerit zestoretic zestril zetia ziac zithromax zocor zofran zoladex zoloft zometa zorbtive zosyn zovirax zyrtec zyvox