What is Ziac
is in a class of drugs called beta-blockers. Bisoprolol is
used to lower blood pressure, lower heart rate, reduce angina
(chest pain), and reduce the risk of recurrent heart attacks.
is a thiazide diuretic (water pill). It helps to lower your
blood pressure and decrease edema (swelling) by increasing
the amount of salt and water you lose in your urine.
is used to treat high blood pressure (hypertension).
may also be used for purposes other than those listed in this
General medical information about Ziac
To reduce nighttime urination, take Ziac before 6
p.m. and preferably in the morning.
Do not stop taking
this medication unless your doctor approves. If you stop
taking your medication, your condition could become much
Who should not take Ziac
Do not take Ziac if you have an allergy to sulfa-based
drugs such as sulfa antibiotics. You may have an allergic
reaction to hydrochlorothiazide.
Before taking this
medication, tell your doctor if you have:
- a heart condition such as low blood pressure, heart
block, a pacemaker, or heart failure, or any other heart
- a collagen
vascular disease such as systemic lupus erythematosus;
- kidney disease;
- liver disease;
- any type of circulatory disease; or
You may not be able to take Ziac, or you
may require a lower dose or special monitoring during treatment
if you have any of the conditions listed above.
is in the FDA pregnancy category C. This means that it is
not known whether Ziac will harm an unborn baby. Do not
take this medication without first talking to your doctor
if you are pregnant.
Ziac passes into breast milk
and may harm a nursing infant. Do not take this medication
without first talking to your doctor if you are breast-feeding
How should take Ziac Take Ziac exactly as directed by your doctor. If
you do not understand these directions, ask your pharmacist,
nurse, or doctor to explain them to you.
dose with a full glass of water.
To reduce nighttime
urination, take Ziac before 6 p.m. and preferably in the
Do not stop taking this medication unless
your doctor approves. If you stop taking your medication,
your condition could become much worse.
at room temperature away from moisture and heat.
If you miss a dose: Take the missed dose as soon as you remember. However,
if it is almost time for your next dose, skip the missed
dose and take only your next regularly scheduled dose. Do
not take a double dose of this medication.
What happens if you overdose: Seek emergency medical attention.
of an bisoprolol and hydrochlorothiazide overdose include
an irregular heartbeat, seizures, confusion, fainting, coma,
shortness of breath, and wheezing.
Avoid while taking Ziac Avoid a diet high in salt. Too much salt will cause
your body to retain water and will decrease the effects
Avoid prolonged exposure
to sunlight. Ziac may increase the sensitivity of your skin
to sunlight. Use a sunscreen and wear protective clothing
when exposure to the sun is unavoidable.
overheated in hot weather. It is easy to become dangerously
dehydrated while taking hydrochlorothiazide.
caution when driving, operating machinery, or performing
other hazardous activities. Ziac may cause dizziness or
drowsiness. If you experience dizziness or drowsiness, avoid
these activities. Also use caution when rising from a sitting
or lying position.
Use alcohol cautiously. Alcohol
may further lower blood pressure and increase drowsiness
and dizziness while you are taking Ziac.
surgery, tell your doctor or dentist that you are taking
Possible side effects of Ziac If you experience any of the following serious side
effects, stop taking Ziac and seek emergency medical attention:
- an allergic reaction (difficulty breathing; closing
of your throat; swelling of your lips, tongue, or face;
- yellow skin or eyes;
- abnormal bleeding or bruising;
- a slow or irregular heartbeat, chest pain;
- swelling of your feet and lower legs, or sudden
- cold or blue feet and hands; or
Other, less serious side effects may be more
likely to occur. Continue to take Ziac and talk to your
doctor if you experience
headache or fatigue;
- tingling or numbness in your
arms, legs, hands, or feet;
- excessive urination
or increased hunger or thirst;
- nausea or decreased
- diarrhea, constipation, gas, nausea,
- weak pulse;
- muscle weakness
- depression or nightmares; or
sensitivity to sunlight.
Side effects other than
those listed here may also occur. Talk to your doctor about
any side effect that seems unusual or that is especially
What other drugs will affect Ziac The following medicines may decrease the effectiveness
- cholestyramine (Questran) and colestipol
- nonsteroidal anti-inflammatory drugs
(NSAIDs) such as ibuprofen (Motrin, Advil), ketoprofen (Orudis,
Orudis KT, Oruvail), and naproxen (Naprosyn, Anaprox, Aleve);
- other commonly used NSAIDs, including diclofenac
(Cataflam, Voltaren), etodolac (Lodine), fenoprofen (Nalfon),
flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac
(Toradol), mefenamic acid (Ponstel), nabumetone (Relafen),
oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril),
and tolmetin (Tolectin).
Larger doses of Ziac may
be needed if you are taking any of the medicines listed
Before taking bisoprolol and hydrochlorothiazide,
tell your doctor if you are taking any of the medicines
- Oral diabetes medications such as
glipizide (Glucotrol), glyburide (Micronase, Glynase, Diabeta),
chlorpropamide (Diabinese), tolazamide (Tolinase), and tolbutamide
(Orinase) may not be as effective in lowering your blood
sugar when you are taking Ziac. Your diabetes therapy may
have to be adjusted.
- Lithium (Lithobid, Eskalith,
others) generally should not be taken with Ziac because
dangerous side effects may result.
- Other drugs
that lower blood pressure must be used very cautiously.
Very low blood pressure can result. Some drugs commonly
used to lower blood pressure include acebutolol (Sectral),
atenolol (Tenormin), bisoprolol (Zebeta), carteolol (Cartrol),
labetalol (Trandate, Normodyne), propranolol (Inderal),
pindolol (Visken), timolol (Blocadren), benazepril (Lotensin),
enalapril (Vasotec), captopril (Capoten), fosinopril (Monopril),
moexipril (Univasc), quinapril (Accupril), ramipril (Altace),
amlodipine (Norvasc), bepridil (Vascor), diltiazem (Cardizem,
Dilacor), felodipine (Plendil), isradipine (Dynacirc), nicardipine
(Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop),
and verapamil (Calan, Verelan, Isoptin).
other than those listed here may also interact with Ziac or
affect your condition. Talk to your doctor and pharmacist
before taking any prescription or over-the-counter medicines.