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Zoladex

What is Zoladex

Zoladex is a man-made protein that is like a hormone in the body called gonadotropin-releasing hormone (GnRH). Zoladex decreases levels of testosterone in men and estrogen in women.

Zoladex is used in the treatment of endometriosis, to thin the endometrial layer (lining of the uterus) prior to surgery for abnormal uterine bleeding, and some types of prostate and breast cancer.

Zoladex may also be used for purposes other than those listed in this medication guide.

General medical information about Zoladex

Zoladex may cause decreased bone mineral density with prolonged use. Smoking, frequent alcohol use, family history of osteoporosis, and the use of certain medications may increase the risk of bone loss. Talk to your doctor about the risk of decreased bone mineral density.

Initially, Zoladex may cause symptoms of your condition to worsen temporarily. Contact your doctor if symptoms do not improve within several weeks of starting treatment.

If you are a pre-menopausal female, notify your doctor if your menstrual period continues to occur. Zoladex usually stops menstruation. Delayed or missed doses of Zoladex may cause ovulation or menstrual bleeding. Following treatment with Zoladex, there may be a delay before the return of regular menstrual periods. Check with your doctor if your period does not restart within a few months of ending treatment.

Do not take Zoladex if you are pregnant or could become pregnant during treatment. Zoladex is known to be harmful to an unborn baby. A nonhormonal method of birth control must be used during treatment with Zoladex to ensure prevention of pregnancy. Although Zoladex may stop ovulation and menstruation, a nonhormonal method of birth control must also be used. If a dose of Zoladex is missed or delayed, ovulation and/or breakthrough bleeding may occur. A nonhormonal method of birth control must also be used until the return of menstruation or for at least 12 weeks following treatment with Zoladex.

What you should find out before taking Zoladex

Do not use Zoladex without first talking to your doctor if you have
- osteoporosis or low bone density;
- pain or difficulty passing urine; or
- spinal cord injury.

You may not be able to take Zoladex, or you may require a dosage adjustment or special monitoring if you have any of the conditions listed above.

Do not take Zoladex if you are pregnant or could become pregnant during treatment. Zoladex is known to be harmful to an unborn baby. A nonhormonal method of birth control must be used during treatment with Zoladex to ensure prevention of pregnancy. Although Zoladex may stop ovulation and menstruation, a nonhormonal method of birth control must also be used. If a dose of Zoladex is missed or delayed, ovulation and/or breakthrough bleeding may occur. A nonhormonal method of birth control must also be used until the return of menstruation or for at least 12 weeks following treatment with Zoladex.

It is not known whether Zoladex passes into breast milk. Do not take Zoladex without first talking to your doctor if you are breast-feeding a baby.

How should take Zoladex

Zoladex is administered by a healthcare professional as a subcutaneous (under the skin) injection into the abdomen (stomach). If Zoladex is being administered at home, your healthcare provider will give you detailed instructions regarding how to administer the injection.

Zoladex is administered every 28 days or every 12 weeks, depending upon the formulation being used and the condition being treated. Your doctor will tell you how often you will need an injection. It is very important to receive each injection at the scheduled time, to maintain effectiveness of the medication.

Initially, Zoladex may cause symptoms of your condition to worsen temporarily. Contact your doctor if symptoms do not improve within several weeks of starting treatment.

Your doctor may want you to have blood tests or other medical evaluations during treatment with Zoladex to monitor progress and side effects.

Your healthcare provider will store Zoladex as directed by the manufacturer. If you are storing Zoladex at home, your healthcare provider will provide storage instructions.

If you miss a dose:

It is important not to miss a dose of Zoladex. Contact your doctor immediately if you miss a dose of this medication.

What happens if you overdose:

An overdose of Zoladex is unlikely to threaten life. Notify your doctor immediately or call an emergency room or poison control center for advice if an overdose is suspected.

Symptoms of a Zoladex overdose are not known.

Avoid while taking Zoladex

Avoid activities such as smoking and frequent alcohol use that may increase the risk of bone loss. Zoladex may cause decreased bone mineral density with prolonged use. Talk to your doctor about the risk of decreased bone mineral density.

Possible side effects of Zoladex

Zoladex may cause decreased bone mineral density with prolonged use. Smoking, frequent alcohol use, family history of osteoporosis, and the use of certain medications may increase the risk of bone loss. Talk to your doctor about the risk of decreased bone mineral density.

Initially, Zoladex may cause symptoms of your condition to worsen temporarily. Contact your doctor if symptoms do not improve within several weeks of starting treatment.

If you are a pre-menopausal female, notify your doctor if your menstrual period continues to occur. Zoladex usually stops menstruation. Delayed or missed doses of Zoladex may cause ovulation or menstrual bleeding. Following treatment with Zoladex, there may be a delay before the return of regular menstrual periods. Check with your doctor if your period does not restart within a few months of ending treatment.

Seek emergency medical attention or notify your doctor immediately if you experience any of the following serious side effects:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- menstrual bleeding or breakthrough bleeding;
- difficulty passing urine; or
- pain, redness, or irritation at the injection site.

Other side effects may also occur. Notify your doctor if you experience
- decreased sexual desire or ability (impotence);
- dizziness or drowsiness;
- depression or mood changes;
- headache;
- hot flushes or sweating;
- decreased appetite, nausea, or diarrhea;
- breast swelling or tenderness, or decrease in breast size;
- vaginal dryness;
- insomnia; or
- skin rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Zoladex

It is not known whether other medications will interact with Zoladex. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products during treatment with Zoladex.

All prescription drugs:

A
abilify accupril accutane acetaminophen aciphex actifed actonel actos acyclovir adalat adderall adipex advair advil albuterol alesse aleve allegra allopurinol amaryl ambien amiodarone amitriptyline amoxicillin amoxil amphetamine anacin aprazolam aricept asacol aspirin atenolol ativan atorvastatin atrovent augmentin avandia avapro avastin avelox azmacort
B
baclofen
bactrim bactroban baycol benadryl bextra biaxin boniva bontril buspar buspirone
C
caduet campral camptosar capoten captopril cardizem cardura carisoprodol casodex catapress cefzil celebrex celexa cellcept cephalexin cialis cipro ciprodex clarinex claritin climara clindamycin clonazepam clonidine codeine codeprex combivent combivir concerta copaxone coreg coricidin cotrim coumadin cozaar crestor cubicin cyclobenzaprine cymbalta
D
darvocet demerol depakote desogen detrol dextromethorphan diazepam diclofenac didrex diflucan digoxin dilantin diltiazem dimetapp diovan diprivan ditropan doxazosin doxycycline drixoral duragesic dyazide
E
effexor elavil elocon eloxatin emend enalapril enbrel endocet engerix-b entex epogen epzicom erbitux ertaczo ery-tab erythromycin estradiol evista 
F
fabrazyme famotidine fazaclo fenofibrate fioricet fiorinal flexeril flomax flonase flovent fluoxetine fosamax fosrenol furosemide  
G
gabapentin gamimune gemfibrozil gemzar glipizide glucophage glucotrol glucovance glyburide glyburide guaifenesin guaifenex 
H
herceptin humalog humira hydroxyzine hyzaar  
I
ibuprofen imdur imitrex imodium inderal insulin integrilin iressa 
K
kaletra keflex kenalog keppra ketek klonopin kytril  
L
lamictal lamisil lanoxin lantus lasix lescol levaquin levitra levothyroxine levoxyl lexapro lidoderm lipitor lisinopril lithium lorazepam lortab lotensin lotrel lotrisone lovenox lupron luveris  
M
macrobid magnevist meclizine medroxyprogesterone meridia metformin methadone methamphetamine methotrexate methylphenidate methylprednisolone metoclopramide metoprolol metronidazole miacalcin minocycline mobic monopril morphine motrin myfortic  
N
naproxen nasacort nasonex natrecor neulasta neupogen neurontin nexium nifedipine nitrofurantoin norco nortriptyline norvasc  
O
omeprazole omnicef orthovisc oxybutynin oxycodone oxycontin oxytrol  
P
paraplatin patanol paxil pegasys penicillin pepcid percocet percodan percogesic phendimetrazine phenergan phentermine phenytoin plavix plendil potassium pravachol prednisone premarin prempro prevacid prilosec prinivil procrit promethazine propecia propofol propoxyphene propranolol protonix proventil provigil prozac pseudoephedrine pulmicort  
R
ranitidine rebetol reglan relafen relpax remeron remicade renagel renova rhinocort riomet risperdal risperidone ritalin rituxan rocephin rogaine roxicet  
S
sanctura seasonale sensipar serevent seroquel serzone singulair skelaxin soma somavert sonata spiriva spironolactone strattera striant sustiva synagis synthroid 
T
tamoxifen tavist taxol taxotere tegretol temazepam tenormin tenuate tequin terazosin tetracycline tiazac tindamax titralac tobradex topamax toprol tramadol trazodone triamcinolone triaminic triamterene tricor trileptal trimox triphasil trizivir truvada tylenol 
U
ultane ultracet ultram uroxatral
V
valium valtrex vaniqa vasotec velcade verapamil viagra vicodin vicoprofen vidaza viracept viread vytorin  
W
warfarin wellbutrin  
X
xalatan xanax xenical xifaxan xolair xopenex xyrem  
Y
yasmin 
Z
zanaflex zantac zavesca zelnorm zemplar zerit zestoretic zestril zetia ziac zithromax zocor zofran zoladex zoloft zometa zorbtive zosyn zovirax zyrtec zyvox