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Zoloft

What is Zoloft

Zoloft is in a class of drugs called selective serotonin reuptake inhibitors. Zoloft affects chemicals in the brain that may become unbalanced and cause depression, panic or anxiety, obsessive or compulsive symptoms, or other psychiatric symptoms.

Zoloft is used to treat depression, obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder, also known as social phobia.

Zoloft may also be used for purposes other than those listed in this medication guide.

General medical information about Zoloft

Do not stop taking Zoloft without first talking to your doctor. It may take 4 weeks or more for you to start feeling better and you may experience unpleasant side effects if you stop taking Zoloft suddenly.

What you should find out before taking Zoloft

Do not take Zoloft if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) during the last 2 weeks. Serious, and sometimes fatal, reactions have occurred when these medicines have been used together.

Do not take Zoloft if you are taking pimozide (Orap). A dangerous drug interaction could result.

Before taking Zoloft, tell your doctor if you
- have liver disease;
- have kidney disease;
- suffer from seizures; or
- suffer from mania or have suicidal thoughts.

You may not be able to take Zoloft, or you may need a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Zoloft is in the FDA pregnancy category C. This means that it is unknown whether it will be harmful to an unborn baby. Do not take Zoloft without first talking to your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether Zoloft passes into breast milk. Do not take Zoloft without first talking to your doctor if you are breast-feeding a baby.

How should take Zoloft

Take Zoloft exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each tablet with water.

The Zoloft Oral Concentrate must be diluted before taking a dose. Use the dropper provided to measure a dose of the liquid. Mix the prescribed amount with 4 oz (one-half cup) of water, ginger ale, lemon/lime soda, lemonade, or orange juice only. Do not use any liquids other than those listed to dilute the concentrate. A slight haze may appear after mixing, this is normal. Drink this mixture immediately after mixing. Do not save any diluted concentrate for later use.

Try to take Zoloft at the same time each day.

Zoloft may be taken with or without food.

Do not stop taking Zoloft without first talking to your doctor. It may take 4 weeks or more for you to start feeling better and you may experience unpleasant side effects if you stop taking Zoloft suddenly.

Store Zoloft at room temperature away from moisture and heat.

If you miss a dose:

Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if you overdose:

Seek emergency medical attention.

Symptoms of a Zoloft overdose include nausea, vomiting, tremor, seizures, agitation, drowsiness, hyperactivity, and enlarged pupils.

Avoid while taking Zoloft

Use caution when driving, operating machinery, or performing other hazardous activities. Zoloft may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness or dizziness while taking Zoloft.

Possible side effects of Zoloft

If you experience any of the following serious side effects, stop taking Zoloft and contact your doctor immediately or seek emergency medical treatment:
- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
- an irregular heartbeat or pulse;
- low blood pressure (dizziness, weakness);
- high blood pressure (severe headache, blurred vision); or
- chills or fever.

If you experience any of the following less serious side effects, continue taking Zoloft and talk to your doctor:
- headache;
- tremor, nervousness, or anxiety;
- nausea, diarrhea, dry mouth, or changes in appetite or weight;
- sleepiness or insomnia; or
- decreased sex drive, impotence, or difficulty having an orgasm.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Zoloft

Do not take Zoloft if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) during the last 2 weeks. Serious, and sometimes fatal, reactions have occurred when these medicines have been used together.

Do not take Zoloft if you are taking pimozide (Orap). A dangerous drug interaction could result.

Before taking Zoloft, tell your doctor if you are taking any of the following medicines:
- a benzodiazepine such as diazepam (Valium), alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), temazepam (Restoril), triazolam (Halcion), and others;
- a tricyclic antidepressant such as amitriptyline (Elavil), imipramine (Tofranil), doxepin (Sinequan), nortriptyline (Pamelor), and others;
- a phenothiazine including chlorpromazine (Thorazine), thioridazine (Mellaril), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), and others;
- lithium (Lithobid, Eskalith, others) or clozapine (Clozaril);
- almotriptan (Axert), frovatriptan (Frova), sumatriptan (Imitrex), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig);
- carbamazepine (Tegretol) or phenytoin (Dilantin);
- warfarin (Coumadin);
- digoxin (Lanoxin);
- cimetidine (Tagamet, Tagamet HB); or
- bupropion (Wellbutrin, Zyban).

You may not be able to take Zoloft, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Do not take the Zoloft Oral Concentrate without first talking to your doctor if you are taking disulfiram (Antabuse). The oral solution contains alcohol, which may interact with disulfiram.

Drugs other than those listed here may also interact with Zoloft. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

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