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Zyvox

What is Zyvox

Zyvox is an antibiotic in a class of drugs called oxazolidinone antibiotics. Zyvox fights bacteria in the body.

Zyvox is used to treat different types of bacterial infections, such pneumonia and skin infections caused by bacteria. Zyvox is often used to treat infections that may not respond to other antibiotics.

Zyvox may also be used for purposes other than those listed in this medication guide.

General medical information about Zyvox

Foods that have a high level of tyramine can cause a severe reaction when consumed during treatment with Zyvox. Symptoms may include severe headache, large pupils, neck stiffness, nausea, vomiting, sweating, irregular heartbeats, chest pain, and death. Call your doctor immediately if you experience any of these symptoms. The following foods contain high levels of tyramine and should be avoided:
- cheeses, including American, Blue, Boursault, Brick, Brie, Camembert, Cheddar, Emmenthaler, Gruyere, Mozzarella, Parmesan, Romano, Roquefort, Stilton, and Swiss;
- fermented or air-dried meats;
- sauerkraut;
- soy sauce; and
- tap beer (alcoholic and nonalcoholic), red wine (especially Chianti), sherry, vermouth, and other distilled spirits.

Blood problems (low levels of red and white blood cells) have been reported with the use of Zyvox. Your doctor may want to monitor your blood with periodic blood tests during treatment with this medication.

In some cases, use of Zyvox has been associated with the development of lactic acidosis (increased acidity of the blood). Notify your doctor immediately if you develop severe or recurrent nausea or vomiting, which may be signs of lactic acidosis.

As with all antibiotics, pseudomembranous colitis (inflammation of the intestines) has been reported with the use of Zyvox. Contact your doctor immediately if you develop diarrhea during treatment with Zyvox.

Take all of the Zyvox that has been prescribed for you even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated.

What you should find out before taking Zyvox

Before taking this medication, tell your doctor if you:
- have had an allergic reaction to Zyvox;
- have uncontrolled high blood pressure;
- have carcinoid syndrome;
- have untreated hyperthyroidism;
- have pheochromocytoma;
- have kidney disease;
- have liver disease;
- have bone marrow suppression or are taking a medication that can affect bone marrow or blood cells;
- are taking a psychiatric medicine such as venlafaxine (Effexor), nefazodone (Serzone), amitriptyline (Elavil, Endep), amoxapine (Asendin), imipramine (Tofranil), nortriptyline (Pamelor), doxepin (Sinequan), fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), mirtazapine (Remeron), citalopram (Celexa), escitalopram (Lexapro), and others;
- are taking a migraine medicine such as almotriptan (Axert), frovatriptan (Frova), eletriptan (Relpax), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), or zolmitriptan (Zomig); or
- are taking a decongestant or diet aid that contains ingredients such as phenylpropanolamine, pseudoephedrine, ephedrine, phenylephrine, and others.

You may not be able to take Zyvox , or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

The suspension form of this medication contains phenylalanine. People with the disease phenylketonuria (PKU) may need to monitor their intake of this additive.

Zyvox is in the FDA pregnancy category C. This means that it is not known whether Zyvox will be harmful to an unborn baby. Do not take an Zyvox without first talking to your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether Zyvox passes into breast milk. Do not take an Zyvox without first talking to your doctor if you are breast-feeding a baby.

How should take Zyvox

Take Zyvox exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Zyvox can be taken with or without food.

Before taking the suspension, gently mix it by turning the bottle upside down 3 to 5 times. Do not shake. To ensure that you get a correct dose, measure the suspension with a dose-measuring dropper, cup, or spoon, not a regular table spoon. Ask your pharmacist for a dose-measuring device if you do not have one.

Blood problems (low levels of red and white blood cells) have been reported with the use of Zyvox. Your doctor may want to monitor your blood with periodic blood tests during treatment with this medication.

Take all of the Zyvox that has been prescribed for you even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated.

It is important to take Zyvox regularly to get the most benefit.

Store Zyvox at room temperature away from moisture and heat. Use the suspension within 21 days.

If you miss a dose:

Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take only the next one as directed. Do not take a double dose of this medication.

What happens if you overdose:

Seek emergency medical attention if an overdose is suspected.

Symptoms of a Zyvox overdose are unknown but may include decreased activity and difficulty with coordination.

Avoid while taking Zyvox

Foods that have a high level of tyramine can cause a severe reaction when consumed during treatment with Zyvox. Symptoms may include severe headache, large pupils, neck stiffness, nausea, vomiting, sweating, irregular heartbeats, chest pain, and death. Call your doctor immediately if you experience any of these symptoms. The following foods contain high levels of tyramine and should be avoided:
- cheeses, including American, Blue, Boursault, Brick, Brie, Camembert, Cheddar, Emmenthaler, Gruyere, Mozzarella, Parmesan, Romano, Roquefort, Stilton, and Swiss;
- fermented or air-dried meats;
- sauerkraut;
- soy sauce; and
- tap beer (alcoholic and nonalcoholic), red wine (especially Chianti), sherry, vermouth, and other distilled spirits.

Do not take any other prescription or over-the-counter medicines without first talking to your doctor during treatment with Zyvox. Many other medications can interact with Zyvox, possibly resulting in dangerous side effects.

Possible side effects of Zyvox

If you experience any of the following serious side effects, stop taking Zyvox and seek emergency medical attention or contact your doctor immediately:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
- bleeding or bruising; or
- fever with confusion.

Blood problems (low levels of red and white blood cells) have been reported with the use of Zyvox. Your doctor may want to monitor your blood with periodic blood tests during treatment with this medication.

In some cases, use of Zyvox has been associated with the development of lactic acidosis (increased acidity of the blood). Notify your doctor immediately if you develop severe or recurrent nausea or vomiting, which may be signs of lactic acidosis.

As with all antibiotics, pseudomembranous colitis (inflammation of the intestines) has been reported with the use of Zyvox. Contact your doctor immediately if you develop diarrhea during treatment with Zyvox.

Other, less serious side effects may be more likely to occur. Talk to your doctor about any side effects you experience, including the following:
- headache;
- nausea or vomiting;
- insomnia;
- constipation;
- rash;
- dizziness;
- tongue discoloration;
- taste alteration; or
- yeast infection in the mouth.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Zyvox

Zyvox can interact with many other drugs, and the interactions may lead to serious side effects. Do not take Zyvox with any of the following medicines without first talking to your doctor:
- a psychiatric medicine such as venlafaxine (Effexor), nefazodone (Serzone), amitriptyline (Elavil, Endep), amoxapine (Asendin), imipramine (Tofranil), nortriptyline (Pamelor), doxepin (Sinequan), fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), mirtazapine (Remeron), citalopram (Celexa), escitalopram (Lexapro), and others;
- a migraine medicine such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), or zolmitriptan (Zomig); or
- a decongestant or diet aid that contains ingredients such as phenylpropanolamine, pseudoephedrine, ephedrine, phenylephrine, and others , found in many prescription and over-the-counter cough and cold products and diet aids.

Drugs other than those listed here may also interact with Zyvox. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

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B
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C
caduet campral camptosar capoten captopril cardizem cardura carisoprodol casodex catapress cefzil celebrex celexa cellcept cephalexin cialis cipro ciprodex clarinex claritin climara clindamycin clonazepam clonidine codeine codeprex combivent combivir concerta copaxone coreg coricidin cotrim coumadin cozaar crestor cubicin cyclobenzaprine cymbalta
D
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E
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F
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G
gabapentin gamimune gemfibrozil gemzar glipizide glucophage glucotrol glucovance glyburide glyburide guaifenesin guaifenex 
H
herceptin humalog humira hydroxyzine hyzaar  
I
ibuprofen imdur imitrex imodium inderal insulin integrilin iressa 
K
kaletra keflex kenalog keppra ketek klonopin kytril  
L
lamictal lamisil lanoxin lantus lasix lescol levaquin levitra levothyroxine levoxyl lexapro lidoderm lipitor lisinopril lithium lorazepam lortab lotensin lotrel lotrisone lovenox lupron luveris  
M
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N
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O
omeprazole omnicef orthovisc oxybutynin oxycodone oxycontin oxytrol  
P
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S
sanctura seasonale sensipar serevent seroquel serzone singulair skelaxin soma somavert sonata spiriva spironolactone strattera striant sustiva synagis synthroid 
T
tamoxifen tavist taxol taxotere tegretol temazepam tenormin tenuate tequin terazosin tetracycline tiazac tindamax titralac tobradex topamax toprol tramadol trazodone triamcinolone triaminic triamterene tricor trileptal trimox triphasil trizivir truvada tylenol 
U
ultane ultracet ultram uroxatral
V
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W
warfarin wellbutrin  
X
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Y
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Z
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